复方苦参注射液对原发性肝癌患者肝切除术后免疫功能的影响  

Effect of Compound Kushen Injection on immune function for patients with primary liver cancer undergoing hepatectomy

作　　者：何津[1] 张大为[1] 张海光[1] 李磊[1] 王丽莉[1] 马龙滨[1] 张景华[1] 

机构地区：[1]唐山市人民医院,河北唐山063001

出　　处：《中成药》2016年第8期1700-1702,共3页Chinese Traditional Patent Medicine

摘　　要：目的探讨复方苦参注射液(苦参和白土苓)对原发性肝癌患者肝切除术后免疫功能的影响。方法 89例完成肝切除术的原发性肝癌患者术后依据患者的意愿分为治疗组(复方苦参注射液)和对照组(未应用复方苦参注射液),观察两组患者治疗前、后免疫功能的改变。结果治疗组和对照组术前1 d的自然杀伤细胞(NK细胞)水平,辅助T细胞(CD4+)、细胞毒T细胞(CD8+)水平和CD4+/CD8+比值无统计学差异(P>0.05)。术后14 d,治疗组的NK细胞水平,CD4+水平和CD4+/CD8+比值与术前自身比较,和与对照组比较都有明显上升(P<0.05)。结论复方苦参注射液能增强肝切除术后原发性肝癌患者的机体细胞免疫功能,对患者的预后具有积极意义。AIM To investigate the effects of Compound Kushen Injection （Sophorae flavescentis Radix and Heterosmilacis Japonicae Rhizoma） on immune function for patients with primary liver cancer undergoing hepatecto- my. METHODS Based on patients＇ wishes, eighty-nine patients were assigned to two groups： treatment group and the control group. The patients＇ changes of immune function in two groups were observed. RESULTS On the 1 st day before the surgery, there was no significant difference in the activity of peripheral blood natural kill （NK） cells, CD4＋ , CD8 ＋and the ratio of CD4＋/CD8 in the two groups （P 〉0. 05）. On the 14th day after sur- gery, the activity of peripheral blood NK cells, CD4 ＋ and the ratio of CD4 ＋/CD8 in treatment group were signifi- cantly increased （P 〈 0. 05 ） compared with the first day before surgery ; the activity of peripheral blood NK cells, CIM ＋ and the ratio of CD4 ＋/CD8 in treatment group were significantly increased （ P 〈 0. 05 ） compared with the control group. CONCLUSION Compound Kushen Injection can improve immune function and probably improve the prognosis in patients with primary liver cancer undergoing hepatectomy.

关 键 词：复方苦参注射液 原发性肝癌 肝切除术 

分 类 号：R287[医药卫生—中药学]