小剂量阿司匹林的临床应用及其对心肌肥厚心室重构作用的研究进展  

Progress on the clinical application of low-dose aspirin and its role in ventricular remodeling of myocardial hypertrophty

作　　者：张琪[1] 辛雪[1] 薛锋[1] 薛明明[1] 

机构地区：[1]内蒙古医科大学基础医学院生理学教研室,内蒙古呼和浩特010059

出　　处：《基础医学与临床》2016年第9期1310-1312,共3页Basic and Clinical Medicine

摘　　要：阿司匹林的作用广泛,可以治疗中风等许多疾病。不同剂量的阿司匹林疗效不完全相同。小剂量阿司匹林(低于150 mg)能不可逆的抑制环氧化酶(COX-1)活性,防止血栓形成,从而发挥延缓心肌肥厚的心室重构的作用。The effect of aspirin is extensive, which can treat many diseases such as stroke. But curative effect of different doses of aspirin is not same. In recent decades of research,researchers found that low-dose aspirin can irrev- ersiblly inhibit the activity of epoxidase （ COX- 1 ）, blocking the formation of thromboxane A2, inhibiting platelet aggregation, preventing thrombosis, thus it plays a role of delaying the progress of the ventricular remodeling of myocardial hypertrophy.

关 键 词：小剂量阿司匹林 心肌肥厚 心室重构 

分 类 号：R971[医药卫生—药品]