松针叶聚戊烯醇的研究进展  

Research Advances of Polyprenol in Pine Needles

作　　者：梁迪[1] 陈卫卫[1,2,3] 李海涛[2,3] 李媛[1] 罗毅[1] 黄俊善 

机构地区：[1]广西中医药大学,南宁530001 [2]南京中医药大学,南京210023 [3]江苏银杏研究院,江苏邳州221300

出　　处：《中国实验方剂学杂志》2016年第17期198-202,共5页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：广西自然科学基金面上项目(2013GXNSFAA019115);广西卫生厅中医药民族医药继承创新工程立项课题(GZZY13-09)

摘　　要：松针叶为松科松属植物马尾松、湿地松、黄山松、落叶松、黑松、红松等的叶子,在全国各地均有分布,具有悠久的药用历史。聚戊烯醇是松针叶的主要活性成分,与人体内所含的多萜醇结构和生物活性相似,具有抗老年痴呆、抗氧化、保护肝损伤、治疗硬化症等作用。目前对松针叶聚戊烯醇的提取、分离纯化工艺及药理作用研究取得了一定进展,但国内关于其应用于临床的制剂开发尚未见报道。对松针叶聚戊烯醇的深入研究将有利于充分利用我国松针叶资源。本文对目前国内外松针叶中聚戊烯醇的提取和分离纯化方法、含量测定、药理作用、制剂等方面进行总结,并对其研究前景进行展望。从目前的研究状况来看,松针叶聚戊烯醇的分离纯化技术、药理作用机制、制剂开发等方面很值得更深入的研究,尤其是其制剂开发方面。Pine needles are the leaves of Pinus massoniana,P. elliottii,P. taiwanensis,Larix gmelinii,P. Thunbergii,P. Koraiensis and other plants,they distribute throughout the country and have a long pharmaceutical history. Polyprenol is one of the principal constituents in pine needles,which has similar structure and biological activities as dolichol in human body. Previous studies show that polyrenol possesses multiple pharmacological properties, such as anti-alzheimer, anti-oxidation, anti-liver injury, etc. Nowadays, some progress on its extraction, separation, purification and pharmacological activities has been demonstrated,however,research on its pharmaceutical preparations for clinical application is not still reported. Further research is helpful for the development of new medicines and making the most use of pine needles＇ resources. In order to provide valuable references of further research and development for polyprenol in pine needles,we review current research on extraction, separation, purification, determination, pharmacological effects, preparation of polyprenol. Based on the current studies, for the purpose of rational development and applied value, further studies shall be made for the technology of separation and purification,pharmacological mechanism,preparation of polyprenol.

关 键 词：松针叶 聚戊烯醇 提取 分离纯化 药理作用 制剂 

分 类 号：R283.6[医药卫生—中药学] R284.1[医药卫生—中医学]