泛素-蛋白酶体系统在心肌肥厚中的研究进展  

Research Advance of Ubiquitin-Proteasome System in Myocardial Hypertrophy

作　　者：鄢雯[1] 李囡[2] 刘立新[2] 王红霞[3] 李汇华[4] 

机构地区：[1]首都医科大学燕京医学院生物化学教研室,辽宁大连116044 [2]首都医科大学燕京医学院形态教研室,北京101300 [3]首都医科大学基础医学院病理生理教研室,北京100069 [4]大连医科大学第一附属医院心血管研究所,辽宁大连116044

出　　处：《医学综述》2016年第17期3329-3333,共5页Medical Recapitulate

基　　金：国家自然科学基金重点项目(81330003);北京高等学校青年英才项目(YETP1679)

摘　　要：泛素-蛋白酶体系统(UPS)是真核细胞内蛋白质降解的主要途径之一。UPS参与真核细胞的许多生物学功能(如炎症、细胞信号转导、转录调控以及细胞凋亡等)。心肌肥厚是导致多种心血管疾病发病率和病死率升高的独立危险因素之一。心肌肥厚的发生机制极其复杂,蛋白酶体可在心肌肥厚模型中被激活,而蛋白酶体抑制剂能阻止或逆转心肌肥厚。The ublquitin-proteasome system （UPS） is involved in the degradation of most intracellular proteins. It has became clear that the UPS fulfills an important function in most aspects of eukaryotic ceils, such as inflammation, intracellular signaling, transcriptional control and apoptosis. Myocardial hypertrophy is one of the independent risk factors raising cardiovascular disease morbidity and mortality. The mechanism of cardiac hypertrophy is extremely complex, and it＇s found that proteasome can be activated in cardiac hypertro- phy models,and the proteasome inhibitor can prevent and reverse cardiac hypertrophy.

关 键 词：心肌肥厚 泛素-蛋白酶体系统 蛋白酶体抑制剂 

分 类 号：R331.3[医药卫生—人体生理学]