益气温阳固精汤结合西医常规疗法治疗老年原发性慢性肾小球肾炎临床研究  

The clinical research of Yiqi-Wenyang-Gujing decoction and conventional western medicine ;treatment on the elderpatients with chronic glomerulonephritis

作　　者：王志强[1] 

机构地区：[1]广东省广州市黄埔区中医院大内科,510700

出　　处：《国际中医中药杂志》2016年第8期697-700,共4页International Journal of Traditional Chinese Medicine

摘　　要：目的：评价益气温阳固精汤结合西医常规疗法治疗老年原发性慢性肾小球肾炎的临床疗效。方法将符合入选标准的65例患者按随机数字表法分为治疗组（33例）和对照组（32例），对照组采用西药常规疗法治疗，治疗组在对照组基础上配合益气温阳固精汤治疗。治疗8周后观察患者水肿程度、24 h尿蛋白定量及肾功能变化，评价临床疗效。结果治疗后，治疗组24 h尿蛋白定量[（0.8±0.1）g比（1.3±0.7）g，t＝4.625]、血肌酐[（132.0±8.5）μmol/L 比（163.9±6.2）μmol/L，t＝17.242]、血尿素氮[（7.1±2.2）mg/L比（9.2±2.5）mg/L，t＝3.598]均低于对照组（P＜0.01）；肾小球滤过率[（73.9±4.2）ml/（min＆#183;1.73 m2）比（65.4±2.4）ml/（min＆#183;1.73 m2），t＝9.976]高于对照组（P＜0.01）；治疗组水肿缓解程度明显优于对照组（P＝0.049）。治疗组缓解率为78.8%（26/33），对照组为46.9%（15/32），2组比较差异有统计学意义（χ2＝5.800，P＝0.016）。结论益气温阳固精汤结合西医常规疗法可改善老年慢性肾小球肾炎患者的肾功能、缓解水肿程度。Objective To estimate the effect of Yiqi-Wenyang-Gujing decoction combined with the conventional western therapy on the elderly with chronic glomerulonephritis. Methods The 65 patients who conforming to the diagnostic criteria were randomly divided into the treatment group （33 patients） and control group （32 patients） according to the random number table. The control group was treated with the conventional western therapy, and the treatment group was treated with Yiqi-Wenyang-Gujing decoction based on the former treatment. After the treatment of 8 weeks, the curative effect of edema and the 24 hours urine protein and the changes of renal function were observed. Results Compare with the control group, the 24 hours urinary protein （0.8 ±0.1 g vs. 1.3 ± 0.7 g, t=4.625）, the SCr （132.0 ± 8.5μmol/L vs. 163.9 ± 6.2μmol/L, t=17.242） and the BUN （7.1 ± 2.2 mg/L vs. 9.2 ± 2.5 mg/L, t=3.598） of treatment group significantly decreased （P〈0.01）;The glomerular filtration rate of treatment group [（73.9 ± 4.2 ml/（min＆#183;1.73 m2） vs. 65.4 ± 2.4 ml/（min＆#183;1.73 m2）, t=9.976] significantly increased （P〈0.01）. And the degree of edema was relieved more in the treatment group than that of the control group （P=0.049）. The total effective rate of the treatment group was significantly better than that （78.8% vs. 46.9%, P=0.016） of the control group. Conclusion The combined Yiqi-Wenyang-Gujing decoction and western medicine treatment on the elderly with chronic glomerulonephritis could improve the kidney function and relieve edema.

关 键 词：肾小球肾炎 老年人 益气温阳固精汤 中西医结合疗法 白蛋白尿 肾小球滤过率 

分 类 号：R692.31[医药卫生—泌尿科学]