301例卵巢成熟畸胎瘤患者肿瘤直径、CA125、CA199与年龄的相关性分析  

Analysis on the correlations between tumor diameter,CA125,CA199 and age of 301 patients with mature dysembryoma

作　　者：唐妍[1,2] 何茜冬[2] 苏园园[2] 韩燕华[2] 刘晓珊[2] 刘君[2] 吴欣荣[2] 张清学[1] 

机构地区：[1]中山大学孙逸仙纪念医院,广东广州510120 [2]中山大学附属中山医院妇产科,广东中山528403

出　　处：《中国妇幼保健》2016年第17期3461-3463,共3页Maternal and Child Health Care of China

基　　金：中山市医学科研项目(2015J007)

摘　　要：目的探讨卵巢成熟畸胎瘤（MCT）患者肿瘤直径和血清CA125、CA199在不同年龄组的临床特点。方法回顾性分析2012年5月-2014年5月在中山大学附属中山医院妇产科因MCT行手术治疗患者的临床资料，根据患者年龄分为5组：〈20岁29例，20—29岁121例，30～39岁76例，40～49岁55例，≥50岁20例，并进行对比分析。结果共纳入301例患者，MCT平均直径大小以〈20岁组最大，其次是350岁组，30～39岁组最小，差异有统计学意义（P〈0．05）；血清CA199平均水平以〈20岁和≥50岁组最高，以30～39岁组和40—49岁组最低，差异有统计学意义（P〈0．05），而CA125平均水平在5个年龄组中的差异无统计学意义（P〉0．05）。此外，CA199阳性率在5组间比较呈下降趋势，差异有统计学意义（P〈0．05），而CA125阳性率在5组间比较，差异无统计学意义（P〉0．05）。结论绝大多数患者发现MCT的年龄阶段位于20—49岁之间。不同年龄阶段MCT直径大小、CA199水平分布有所不同，这将有助于临床更好地理解和诊断MCT。Objective To explore the clinical characteristics of tumor diameter and serum CA125, CA199 in patients with mature dysembryoma in different age groups. Methods The clinical data of patients with mature dysembryoma treated in Department of Gynecology and Obstetrics in the hospital from May 2012 to May 2014 were analyzed retrospectively, then the patients were divided into five groups according to age： 〈20-year-old group （29 patients）, 20-29-year-old group （121 patients） , 30-39-year-old group （76 patients）, 40-49-year-old group （55 patients）, and ≥50-year-old group （20 patients）, the results were compared and analyzed. Results A total of 301 patients were included in this study. The mean diameter of mature dysembryoma in 〈 20-year-old group was the largest, followed by ≥ 50-year-old group, the mean diameter of mature dysembryoma in 30-39-year-old group was the smallest, there was statistically significant difference （P〈0. 05） . The mean levels of serum CA199 in 〈20-year-old group and ≥50-year-old group were the highest, while mean levels of serum CA199 in 30-39-year-old group and 40-49-year-old group were the lowest, there were statistically significant differences （P〈0. 05 ） . There was no statistically significant difference in mean level of CA125 among five age groups （P〉0. 05 ） . The positive rate of CA199 in five age groups showed decreasing trend, there were statistically significant differences （P〈0. 05） ; there was no statistically significant difference in positive rate of CA125 among five age groups （P〉0. 05） . Conclusion The majority of patients are diagnosed and treated between the ages of 20 and 49 years. The diameter of mature dysembryoma and the serum level of CA199 show different characteristics in different age groups. This can help clinicians understand and diagnose mature dysembryoma better.

关 键 词：卵巢成熟囊性畸胎瘤 CA199 CA125 年龄 

分 类 号：R711.71[医药卫生—妇产科学]