神经梅毒患者淋巴细胞亚群分析  

Analysis of lymphocyte subsets in patients with neurosyphilis

作　　者：张易[1] 黄继伟[2] 许晓英[1] 吕燕[1] 

机构地区：[1]四川自贡市第五人民医院检验科,自贡643020 [2]四川自贡市第一人民医院检验科,自贡643000

出　　处：《中国实用神经疾病杂志》2016年第15期7-9,共3页Chinese Journal of Practical Nervous Diseases

摘　　要：目的分析神经梅毒患者外周血中淋巴细胞亚群的特点,探讨其与神经梅毒发病的关系。方法选取神经梅毒患者52例为研究对象,分为无症状神经梅毒组、早期神经梅毒组与晚期神经梅毒组,选取同期健康体检者50例为健康对照组,采集外周血,运用流式细胞术分析神经梅毒组与健康对照组的外周血淋巴细胞的表达水平。结果神经梅毒患者的CD3^+CD8^+T淋巴细胞数量明显高于健康对照组,差异有统计学意义(P<0.05),神经梅毒患者NK细胞数量显著低于健康对照组;无症状神经梅毒患者的CD3^+T细胞与CD3^+CD8^+T细胞数显著高于早期神经梅毒患者和晚期神经梅毒患者,差异均有统计学意义(P<0.05)。结论神经梅毒患者的T淋巴细胞亚群失衡与NK细胞减少与神经梅毒的发生发展有一定关系。Objective To analyze the subsets of the lymphocyte in peripheral blood in patients with neurosyphilis and investigate the relationship between these cells and onset of neurosyphilis. Methods The subsets of the lymphocyte were analyzed by flow cytometry with immunofluorescent staining in 52 patients with neurosyphilis and 50 healthy controls. Results Neurosyphilis patients＇ CD3＋CD8＋ T lymphocytes numbers were significantly higher than those in healthy controls,the difference was statistically significant （P〈0. 05） ,the numbers of patients with neurosyphilis NK cells were significantly lower than those of the control group （P〈0.05）. Asymptomatic neurosyphilis patients CD3＋ T cells and CD3＋CD8＋ T cells count were significantly higher those in patients with early and late neurosyphilis neurosyphilis （P〈0.05）. Conclusion It is suggested that the change of T lymphocyte subsets and the reduction of NK cells are related to neurosyphilis.

关 键 词：神经梅毒 淋巴细胞 流式细胞仪 

分 类 号：R759.13[医药卫生—皮肤病学与性病学]