血管生成素-1在甲状腺腺瘤中的表达及其与超声造影的相关性分析  

Expression of Angiopoietin-1 in Thyroid Adenoma and the Relationship with Ultrasound Contrast

作　　者：杨维敏[1] 王治国[2] 刘学明[2] 

机构地区：[1]唐山市丰润区第二人民医院,河北唐山064000 [2]河北医科大学附属唐山市工人医院,河北唐山064000

出　　处：《生物技术通讯》2016年第4期548-550,共3页Letters in Biotechnology

摘　　要：目的:以瘤旁正常组织为对照,研究甲状腺腺瘤中血管生成素-1(Ang-1)的表达情况,并分析其与超声造影的相关性,为超声诊断及预后判断提供依据。方法:回顾性分析甲状腺腺瘤患者15例的超声造影检查结果,根据时间强度曲线获得造影参数。用Western印迹检测术后肿瘤及瘤旁标本的Ang-1表达情况,并与超声造影结果进行相关性分析。结果:15例甲状腺腺瘤中,13例造影后肿块与周围甲状腺表现为高回声(86.7%,13/15),2例出现等回声(13.3%,2/15),12例肿块内部均匀增强(80%,12/15);甲状腺腺瘤组平均渡越时间(m TT)、峰值强度(Imax)大于瘤旁组(P<0.05);甲状腺腺瘤较瘤旁组织Ang-1表达明显升高(P<0.05);相关性比较可见Ang-1表达水平与始增时间(RT)、达峰时间(TTP)、m TT的表达呈负相关(P<0.01),与Imax的表达呈正相关(P<0.01)。结论:甲状腺腺瘤中Ang-1较瘤旁组织明显升高,其超声造影指标与Ang-1的表达水平存在相关性,通过甲状腺腺瘤的超声造影,可以为Ang-1的表达水平提供依据,并可能为预后提供参考。Objective： To investigate the angiopoietin-1（Ang-1） levels in thyroid adenoma and peri-tumorous nor-mal tissues, then make correlation analysis between them. Methods： 15 cases of thyroid adenoma patients were an-alysed with ultrasound contrast retrospectively. Imaging parameters were got by time intensity curves. The Ang- 1expression in thyroid specimens was analyzed by Western blot, and performed correlation analysis with the magingparameters of ultrasound contrast, and provided the basis for prognostic judgement. Results： 13 of the 15 caseswith thyroid adenoma were hyper echo, 2 cases were equal echo. The levels of m TT and Imax in thyroid adenomawere higher than that of peri-tumorous normal tissues（P〈0.05）. The more Ang-1 expressed in thyroid adenomathan that in peri-tumorous normal tissues（P〈0.01）. The levels of Ang-1 were negative correlated with RT, TTP,m TT（P〈0.05）, and positive correlated with Imax. Conclusion： The level of Ang-1 is higher in thyroid adenomathan that in peri-tumorous normal tissues. There was an correlationship between imaging parameters of ultrasoundcontrast and Ang-1 levels in thyroid adenoma, it could provide evidence for the level of Ang-1 and provide a ref-erence for prognosis.

关 键 词：甲状腺腺瘤 血管生成素-1 超声造影 

分 类 号：R445[医药卫生—影像医学与核医学]