大疱性系统性红斑狼疮一例  

Bullous systemic lupus erythematosus:a case report

作　　者：闫天萌 左亚刚[1] 张舒[1] 林澜[2] 刘跃华[1] 李丽[1] 张涛[1] 赖雅敏[3] 

机构地区：[1]中国医学科学院北京协和医学院北京协和医院皮肤科,北京100730 [2]沈阳药科大学生命科学与生物制药学院,沈阳110016 [3]中国医学科学院北京协和医学院北京协和医院免疫内科,北京100730

出　　处：《中国麻风皮肤病杂志》2016年第8期468-470,共3页China Journal of Leprosy and Skin Diseases

基　　金：国家自然科学基金(编号:81071301;81371731;81301370)

摘　　要：患者,女,27岁。咳嗽4个月,躯干、四肢红斑、水疱及脱发2个月。皮肤科情况:头顶发稀疏,面部充血性红斑,双手指腹红斑,躯干四肢可见大小不等水疱、血疱,疱壁紧张,尼氏征阴性。外周血红细胞和血红蛋白下降、补体下降,ANA、抗ds-DNA阳性,血清抗VII胶原抗体阳性。患者疱液免疫检测:ANA、抗ds-DNA、抗SSA、抗SSB、抗组蛋白抗体(+),抗RO 52抗体(+++),抗核小体抗体(++),滴度与血液中滴度平行。诊断为大疱性系统性红斑狼疮。A 27-years-old female patient presented with cough for 4 months and erythema, vesicle and hair-loss for 2 months. Physical examination revealed sparse hair on the scalp, erythema on the face and finger pulp, bullas on the trunk and extremities. The bullas were negative in Nikolskys sign. Red blood cells and hemoglobin declined and anti-nuclear antibody, anti-ds DNA, antibody to type VII collagen in peripheral blood were positive. ANA, anti-dsDNA, anti-SSA, anti-SSB, anti-histone, anti-Ro 52 and anti-nucleosome antibodies in blister fluids were positive. The diagnosis of bullous systemic lupus erythematosus was made.

关 键 词：系统性红斑狼疮 大疱性 疱液 

分 类 号：R593.241[医药卫生—内科学]