妊娠期尖锐湿疣的临床特点及对妊娠结局和新生儿预后的影响  

The clinical characteristics of pregnant women with condyloma acuminatum and the influence on pregnancy outcome and neonatal prognosis

作　　者：李娟[1,2] 何克静[1] 尹华春[1] 吴明香[1,2] 

机构地区：[1]成都市传染病医院妇产科,成都610021 [2]成都市第十人民医院妇产科,成都610021

出　　处：《中国性科学》2016年第8期118-121,共4页Chinese Journal of Human Sexuality

摘　　要：目的:探讨妊娠期合并尖锐湿疣的临床特点、临床干预、分娩方式、妊娠结局以及对新生儿的影响。方法:收集妊娠合并尖锐湿疣患者66例(妊娠CA组),同期育龄女性尖锐湿疣患者68例(CA组),同期分娩的正常妊娠孕产妇70例(正常妊娠组),分析孕期尖锐湿疣的临床特点、临床干预效果、分娩方式、妊娠结局以及新生儿感染HPV的情况等。结果:妊娠CA组疣体数量、直径、阴道分泌物中病原菌数量和CA组比较差异均有统计学意义(P<0.05)。妊娠CA组二氧化碳激光治疗后复发率明显高于CA组,差异有统计学意义(P<0.05)。比较孕产妇足月分娩率、流产/早产以及剖宫产率,妊娠CA组中干预患者和正常妊娠组差异均无统计学意义(P>0.05),和未干预患者比较差异均有统计学意义(P<0.05)。妊娠CA干预组与未干预组新生儿Apgar评分、畸形/低体重发生率、HPV阳性率以及6个月随访HPV感染率、呼吸道乳头瘤病发生率差异均无统计学意义(P>0.05)。结论:妊娠期合并尖锐湿疣患者病情较普通患者严重,治疗后复发率较高,临床干预可增加足月产率、降低流产/早产率以及剖宫产率,提示临床应该提醒尖锐湿疣患者彻底治愈后再妊娠,而孕产妇要根据患者病史等尽早发现尖锐湿疣、尽早干预,以减轻对妊娠的影响。Objectives： To investigate the clinical characteristics,clinical intervention,delivery mode,pregnancy outcome and the effect for the newborn in pregnant women with condyloma. Methods： 66 pregnant women with condyloma acuminatum（ pregnancy CA group）,68 childbearing age women with condyloma acuminatum（ CA group）,and 70 normal pregnancy women during the same period were collected. The clinical characteristics,clinical characteristics,delivery mode,pregnancy outcome and neonatal infection of HPV were analyzed.Results： Difference in the number of condyloma,diameter and pathogens of the vaginal discharge between CA group and pregnancy CA group was significant（ P〈0. 05）. The recurrence rate of pregnancy CA group after carbon dioxide laser treatment was significantly higher than that of CA group,with statistically significant difference（ P〈0. 05）. In terms of maternal term delivery rate,abortion / preterm delivery and cesarean section rate between the intervention patients group and normal pregnancy group,the difference was not statistically significant（ P〉0. 05）,however,for pregnancy CA group,the difference between intervention patients group and non- interventional group was significant（ P〈0. 05）. Between interventions group and non- interventional group of pregnancy CA group,the differences in neonatal Apgar score,deformity / low birth weight rate,positive rate of HPV,HPV infection rate after6 months follow- up and respiratory papillomatosis rate had no statistical significance（ P〉0. 05）. Conclusions：The condition of pregnant patients combined condyloma acuminatum is more serious than those of normal CA patients with higher recurrence rate. Clinical intervention can increase the term rate,reduce the rate of abortion and premature delivery. It is suggested that patients should be completely cured before pregnancy,and condyloma acuminatum should be diagnosed and treated early to reduce the influence for pregnancy.

关 键 词：妊娠 尖锐湿疣 妊娠结局 新生儿 人乳头瘤病毒 

分 类 号：R752.5[医药卫生—皮肤病学与性病学]