原成都军区总医院急性冠脉综合征病人质子泵抑制剂用药分析  

Analysis of the utilization of proton pump inhibitors in the patients with acute coronary syndromes in the former General Hospital of Chengdu Military Command

作　　者：梁蓉梅[1] 段玉琴[2] 雍小兰[1] 谭永红[3] 胡婷婷[1] 陈曦[1] 

机构地区：[1]原成都军区总医院临床药学科,成都610083 [2]原成都军区总医院干部病房,成都610083 [3]原成都军区总医院药剂科,成都610083

出　　处：《药学服务与研究》2016年第4期277-281,共5页Pharmaceutical Care and Research

摘　　要：目的:了解原成都军区总医院非ST段抬高急性冠脉综合征(NSTE-ACS)病人质子泵抑制剂(PPIs)的使用情况,评价其使用的合理性。方法:对2013-01至2015-06本院NSTE-ACS病人所用PPIs的使用率、人均用药天数、使用品种数、用药频度(DDDs)、使用强度(use density,UD)和药物利用指数(drug utilization index,DUI)等指标进行回顾性分析。根据欧洲及美国相关指南评价应用的合理性。结果:129例病人均接受抗血小板治疗,其中122例病人采用双联抗血小板治疗(dual antiplatelet therapy,DAPT),CRUSADE出血评分风险中度及以上病人49例,占37.98%,出血风险为(11.00±3.88)%。PPIs使用率90.70%,使用品种数为(1.32±0.57)种,人均用药天数(7.05±4.63)d,UD为129.15DDDs,DUI为1.71。使用率及DDDs前3位均为泮托拉唑、埃索美拉唑、兰索拉唑;DUI前3位为奥美拉唑、埃索美拉唑和泮托拉唑。多数病人存在过度使用PPIs情况。结论:本院NSTE-ACS病人PPIs使用率高、品种选择不当、过度使用,有待进一步规范和加强管理。Objective：To investigate the utilization of proton pump inhibitors（PPIs）in the patients with non-ST-segment elevation acute coronary syndromes（NSTE-ACS）in the former General Hospital of Chengdu Military Command,and also to evaluate its rational utilization.Methods：A retrospective analysis was made on such indicators as application rate,duration of medication on the average per person,drug categories,frequency of medication（DDDs）,use density（UD）and drug utilization index（DUI）of PPIs in NSTE-ACS patients of the hospital from January 2013 to June 2015.Rationality of PPIs application was also evaluated in accordance with the European and US guidelines.Results：Anti-platelet therapy was given to all the 129 patients,of whom 122 received dual anti-platelet therapy（DAPT）.There were 49 patients with moderate or high risks of CRUSADE bleeding scores,accounting for 37.98%,and bleeding risk was（11.00±3.88）%.The application rate,the drug category,the duration of medication on the average per person,UD and DUI of PPIs were 90.70%,（1.32±0.57）,（7.05±4.63）days,129.15 DDDs and 1.71,respectively.For the application rate and DDDs,the top 3were pantoprazole,esomeprazole and lansoprazole,and for DUI the top 3were omeprazole,esomeprazole and pantoprazole.There was excessive use of PPIs in most patients.Conclusion：For the application of PPIs in the NSTE-ACS patients of the hospital,many problems existed,such as high rate of application,improper selection of drug categories and excessive utilization of drugs,which should be brought under control.

关 键 词：质子泵抑制剂 出血 胃肠道 急性冠脉综合征 非ST段抬高 药物利用评审 

分 类 号：R975.2[医药卫生—药品]