环糊精聚合物功能化聚乳酸/聚乙烯基吡咯烷酮共聚物膜的制备与性能  

Preparation and Properties of Poly(lactic acid)-co-Poly(N-vinylpyrrolidone)Copolymer Film Functionalized by β-Cyclodextrin Polymer

作　　者：赵慧[1] 李利燕[1] 高俊[1] 刘瑞娜[1] 赵三平[1] 

机构地区：[1]武汉纺织大学材料科学与工程学院,纺织纤维及制品教育部重点实验室,武汉430200

出　　处：《高分子学报》2016年第9期1221-1228,共8页Acta Polymerica Sinica

基　　金：湖北省自然科学基金(基金号2015CFB324)资助项目

摘　　要：合成了丙烯酸酯封端的PLA-PEG-PLA大分子单体(PELA-DA)与甲基丙烯酸缩水甘油酯(GMA)修饰的β-环糊精聚合物(CDP-g-GMA),不同配比的PELA-DA、CDP-g-GMA及N-乙烯基吡咯烷酮(VP)的DMF溶液经光引发自由基聚合制备了环糊精聚合物功能化聚乳酸/聚乙烯基吡咯烷酮共聚物膜.1H-NMR证实了PELA-DA及CDP-g-GMA大分子单体的成功合成.利用XRD、DTMA、TGA、吸水性及体外降解性等表征方法对合成的共聚物膜的结构与性能进行了表征.XRD测试表明,共聚物膜中PELA-DA及CDP-g-GMA组分的结晶性受到抑制与破坏;吸水性及体外降解测试显示,CDP-g-GMA的引入改善了共聚物膜的亲水性及水解降解性;DTMA及TGA测试结果表明,随着CDP-g-GMA引入量的增加,共聚物膜的储能模量(E')、玻璃化转变温度(Tg)及热稳定性增加.以甲基橙(MO)为水溶性模型药物,考察了共聚物膜对MO负载及释放模式,研究发现,CDP-g-GMA引入量的增加有利于提高MO的负载量,MO经过初期(12 h)爆释后,以一种缓慢的持续的方式进行释放.Acrylate-terminated PLA-PEG-PLA macromer （PELA-DA） and fl-cyclodextrin polymer modified with glycidyl methacrylate （CDP-g-GMA） were synthesized, and copolymer films with different compositions were prepared via UV-initiated free radical polymerization of PELA-DA, CDP-g-GMA and N-vinylpyrrolidone （VP） in DMF. The 1H-NMR analysis confirmed the successful synthesis of PELA-DA and CDP-g-GMA macromers. The structure and properties of the copolymer films were characterized by X-ray diffraction （XRD） , dynamic thermomechanical analysis （DTMA） , thermal gravity analysis （TGA） , water uptake and in vitro degradation. XRD exhibited that the crystallinity of PELA-DA and CDP-g-GMA components was suppressed and disturbed in the copolymer films. The water uptake and in vitro degradation measurements showed that the hydrophilicity and hydrolytic degradation of the copolymer films were improved due to the introduction of CDP-g-GMA macromer. DTMA and TGA results displayed that storage modulus （E＇） , glass transition temperature （Tg） and thermal stability of the resultant copolymer films increased as the contents of fl-cyclodextrin polymer macromer incorporated increased. In addition, using methyl orange （MO） as a water- soluble model drug,the MO loading and release profiles of the copolymer films were evaluated. It was found that the MO loading amounts of the films increased with the increase of incorporated CDP-g-GMA content. After a burst release of 12 h at the first stage,the MO release profile was in a slow and sustained manner.

关 键 词：大分子单体 环糊精 共聚物膜 降解性 药物释放 

分 类 号：TB383.2[一般工业技术—材料科学与工程] TQ317[化学工程—高聚物工业]