T2DM合并骨折的老年患者VitD骨钙素与骨密度的关系  

Elderly Patients with T2DM Combined Fracture VitD,Osteocalcin and BMD of the Relationship

作　　者：刘国亭[1] 孙宏武[1] 王利[1] 王琨[1] 闫宇旺 

机构地区：[1]包头市第三医院骨科,内蒙古包头014040

出　　处：《内蒙古医学杂志》2016年第4期434-436,共3页Inner Mongolia Medical Journal

基　　金：包头市科技局卫生基金项目(项目编号:Wsjj2015080)

摘　　要：目的探讨2型糖尿病合并骨折的老年患者25(OH)Vit D、骨钙素与骨密度的关系。方法将2014年10月至2015年10月收治的103例年龄≥60岁老年骨折患者分为实验组与对照组,实验组为合并T2DM骨折患者34例,对照组为非T2DM骨折患者69例,收集临床资料、骨密度、骨钙素、25(OH)Vit D等,并进行统计学处理。结果病例组的腰椎骨密度及髋部骨密度均较对照组明显降低,差异具有统计学意义(P<0.05);比较两组不同骨量的Vit D水平,在骨量正常者中比较差异具有统计学意义(P<0.05),骨量减少与骨质疏松中比较差异无统计学意义(P>0.05),两组中骨质疏松患者血清25(OH)Vit D水平均较骨量正常患者低,差异具有统计学意义(P<0.05)。不同骨量患者血清骨钙素水平比较,T2DM及非T2DM中合并骨质疏松患者较骨量正常及骨量减少患者整体骨钙素水平明显增高,差异具有统计学意义(P<0.05),两组间比较差异无统计学意义(P>0.05)。结论 T2DM合并骨折老年患者总体骨密度水平较低,T2DM骨质疏松患者25(OH)Vit D水平较低,骨钙素水平增高。检测25(OH)Vit D、骨钙素及骨密度有助于提前预测骨质疏松的风险。Objective To investigate the elderly patients with type 2 diabetes mellitus and fracture bone metabolic markers and bone mineral density and osteoporosis. Methods At the October 2014 - October 2015, 103cases of fracture patients who be admitted to hospital and age 60 years or more are divided into experimental group and control group, experimental group for T2DM fractures patients 34 cases, control group for 69 cases of fracture of T2DM patients, two groups of clinical information collection, bone mineral density （using dual - en- ergy X- ray absorptiometry （dexa） by the image physicians to assist complete）, laboratory examination of blood routine, biochemical and laboratory data, such as the bone markers （laboratory tests are performed by the hospi- tal clinical laboratory physician to assist）. Clinical data records in the two groups in elderly patients with frac- ture, bone density, serum calcium and blood uric acid, alkaline phosphatase and osteocalcin, 25 （OH） vitamin D, NLR （neutrophils/lymphocyte ratio）, and other indicators, and statistical processing. Results Density and hip bone mineral density in case group were significantly lower than the control group, a statistically significant difference（P 〈 0.05） ;Compare two groups of different bone mass VitD levels, in the normal bone mass is statis- tically significant difference（P 〈 0.05）, bone loss and osteoporosis in comparison difference has no statistical sig- nificance（P 〉0.05）, two groups of osteoporosis in patients with serum 25 （OH） VitD levels are relatively low bone mass in patients with normal, statistically significant difference（P 〈 0.05）. Different bone mass in patients with serum osteocalcin level comparison of T2DM and the combination of osteoporosis in T2DM patients than in patients with normal bone mass and bone mass reduction of osteocalcin level increased obviously, statistically sig- nificant difference（P 〈 0.05）, there was no statistically significant difference is compared between tw

关 键 词：老年 糖尿病 25(OH)Vit D 骨钙素 骨密度 

分 类 号：R674[医药卫生—外科学]