心欣舒胶囊对实验性心肌梗死大鼠的保护作用及机制  

Protective effect and mechanisms of Xinxinshu Capsules on experimental myocardial infarction in rats

作　　者：申旭霁[1,2] 常润 苟伟[2] 李西宽[2] 孙强[2] 

机构地区：[1]西安医学院,西安710021 [2]西安交通大学医学部基础医学院,西安710061 [3]西安交通大学医学部药学院,西安710061

出　　处：《西北药学杂志》2016年第5期489-492,共4页Northwest Pharmaceutical Journal

摘　　要：目的探讨心欣舒胶囊对实验性心肌梗死大鼠心肌的保护作用及冠状动脉新生血管生成的影响。方法采用结扎冠状动脉左前降支的方法制作大鼠心肌梗死模型,观察中成药心欣舒胶囊对实验性心肌梗死大鼠心肌梗死面积及血管生成的影响。建立心肌梗死模型4周后采用Mallory染色检测心肌梗死面积及免疫组化染色测定梗死边缘区血管内皮舒张因子(VEGF)、碱性成纤维细胞生长因子(bFGF)和Ⅷ因子的表达量以及血管面密度。结果心欣舒胶囊大、小剂量治疗组大鼠心肌梗死面积均明显小于模型组,而心肌梗死边缘区VEGF、bFGF和Ⅷ因子的表达量以及血管面密度较对照组均明显增加。结论心欣舒胶囊能减轻实验性心肌梗死大鼠的梗死面积,促进心肌冠脉侧枝循环的生成,对缺血心肌具有保护作用。Objective To investigate the protective effects of Xinxinshu Capsules on experimental myocardial infarction in rats induced by left anterior descending branch of coronary artery.Methods Left anterior descending coronary arteries of rats were ligated to produce acute myocardial infarction model.Immunohistochemisty was used to detect the contents of VEGF,bFGF,Ⅷfactor and vascular density in the edge of infarct section,and the infarct area was measured.Results The infarct areas in treatment groups were obviously less than in model group.The contents of VEGF,bFGF and Ⅷ factor in the edge of infarct section and vascular density in treatment groups were significantly increased compared with those in model group.Conclusion Xinxinshu Capsules can decrease the infarct area and stimulate angiogenesis of the collateral branch of coronary artery in ischemic myocardium of rats,and showed good protective effect on myocardial ischemia.

关 键 词：心欣舒胶囊 血管生成 心肌梗死 

分 类 号：R965[医药卫生—药理学]