新型镇静催眠药Z-药物类及其代谢物的检测技术综述  

A Review for Determination Methods of Z-drugs and Their Metabolites

作　　者：杨士云[1] 袁增平[1] 张瑛[1] 张伟[1] 

机构地区：[1]北京市公安局法医检验鉴定中心,北京100192

出　　处：《现代科学仪器》2016年第4期5-11,19,共8页Modern Scientific Instruments

摘　　要：Z-药物类佐匹克隆、唑吡坦、扎来普隆为新型镇静催眠药，因其作用快，毒副作用小而受到失眠者的青睐。近几年来，在法庭毒物分析中，经常出现此类药物检出阳性的案例报道，引起了广大毒物分析者的关注。本文简要介绍了此类药物在生物样品中的主要代谢物。系统综述了生物检材中此类药物及其代谢物的前处理过程及其回收率，常用的仪器分析方法，特别给出了使用LC-MS／MS检测技术时使用的分析柱、流动相及药物的LOD或LOQ。介绍了分析此类药物需要注意的具体事项及保存血液中易分解药物的技术。旨在为刑事工作者提供参考。The Z-drugs zopiclone, zolpidem and zaleplon ,which are new sedative hypnotic drugs,have become the most popular sleep agents used in short-term trentment of insomnia,becase of their short action and small toxic and side effects. In recent years,these drugs are frequently appeared in forensic cases,and have been paid attention by toxicological analysts. This paper briefly introduces the main metabolites of these drugs in the biological specimens, systematically summarizes the pretreatment process of these drugs and metabolites in biological specimens and their recovery, common analysis methods used instrument, especially gives the analysis column, the mobile phase and LODs and LOQs of the drugs in the using LC-MS / MS detection technology. This paper introduces the specific issues that need to be paid attention to in the analysis of these drugs and the techniques for the preservation of the drugs in the blood. The study aims to provide a reference for the criminal workers.

关 键 词：佐匹克隆 唑吡坦 扎来普隆 代谢物 检测技术 

分 类 号：D919[医药卫生—法医学]