何首乌不同提取物干预糖尿病大鼠的初步药效学分析  

Pharmacodynamic Assay of Different Extracts from Polygonum multiflorum on Diabetic Rats

作　　者：唐静[1] 曾雅莉[1] 

机构地区：[1]华中科技大学同济医学院附属梨园医院,湖北武汉430077

出　　处：《湖北中医药大学学报》2016年第4期35-38,共4页Journal of Hubei University of Chinese Medicine

基　　金：华中科技大学自主创新基金(项目编号:2014QN072)

摘　　要：目的探讨何首乌不同溶剂提取物在治疗糖尿病方面是否具有药效学优势,比较不同溶剂对糖尿病及其并发症的影响。方法高脂饲料喂养联合腹腔內注射小剂量四氧嘧啶的方法,造成糖尿病大鼠模型,分别用二甲双胍、何首乌水提物、何首乌乙醇提取物、何首乌正丁醇提取物进行干预,观察给药前后大鼠体重、血糖、血脂值以及肝组织结构变化。结果给药6周后发现3种何首乌提取物与模型组相比,显著性降低了糖尿病大鼠的血糖以及TG、TC、LDL-C,升高了HDL-C,减轻肝细胞脂肪样变性。结论 3种何首乌提取物对糖尿病大鼠模型血糖、血脂有明显的改善作用,提示其对糖尿病合并血脂异常有治疗作用。Objective To study the pharmacodynamics of different extracts from Polygonum multiflorum on diabetic rats. Methods Diabetic rats were induced by intraperitoneal injection of a small dose of alloxan and fed with high -fat diet. The rats were divided into different groups and given metformin, water extract, ethanol extract, n - butyl alcohol ex- tract from Polygonum multiflorum, evaluate the efficacy by measuring the body weight, blood glucose, blood lipid value and observed the hepatic tissues pathology. Results Compared with control group, the three different extracts from Po- lygonum multiflorum were effective in reducing blood glucose, TG, TC, LDL - C, elevating HDL - C in diabetic rats. Conclusion The three different extracts from Polygonum multifiorum have obvious improvement in blood glucose and blood lipid of diabetic rats, suggesting a therapeutic effect on diabetic dyslipidemia.

关 键 词：糖尿病 何首乌提取物 药效学 血糖 

分 类 号：R285.5[医药卫生—中药学]