一线ART治疗方案对HIV合并HBV感染患者的临床疗效观察  

Therapeutic effects of first-line ART therapeutic schedule for patients with combined infection of HIV with HBV

作　　者：韦永孜[1] 姚钦江[1] 黄丽静[1] 

机构地区：[1]广西壮族自治区钦州市第一人民医院感染科,535000

出　　处：《河北医药》2016年第17期2608-2610,共3页Hebei Medical Journal

摘　　要：目的探讨一线ART治疗方案对HIV合并HBV感染患者的临床疗效。方法选择2012年4月至2014年5月首诊治疗的46例HIV合并HBV感染患者,入组46例患者均采取一线ART治疗方案,分别于治疗前、治疗3个月、6个月、12个月检测患者CD_4^+T细胞计数变化、病毒转阴率以及肝功能变化情况,并记录患者治疗期间不良反应发生情况。结果治疗3、6、12个月,患者CD_4^+T细胞计数水平显著高于治疗前,差异有统计学意义(P<0.05),且随着治疗时间的延长,患者CD_4^+T细胞计数显著增加(P<0.05);治疗后患者丙氨酸氨基转移酶水平较治疗前显著降低(P<0.05),患者血肌酐水平较治疗前显著升高(P<0.05);随着治疗时间的延长,患者HIV RNA与HBV DNA病毒转阴率均显著增高(P<0.05),且治疗12个月,患者HIV RNA与HBV DNA病毒转阴率均达到100%。结论一线ART治疗方案能够有效提高HIV/HBV合并感染患者免疫功能、改善患者肝功能水平,对HIV、HBV病毒均能有效控制,且患者耐受性较好,安全可靠。Objective To observe the therapeutic effects of first-line ART therapeutic schedule for patients with combined infection of human immunodeficiency virus（ HIV） with hepatitis B virus（ HBV）. Methods Forty-six patients with combined infection of HIV with HBV who were firstly treated in our hospital from April 2012 to were enrolled in the study. All the patients were treated by first-line ART therapeutic schedule,and the changes of CD_4~＋T cell counts,the negative conversion rate of virus,changes of liver function and the incidence of adverse reactions during treatment were detected and analyzed before treatment and on 3 months,6 months,12 months after treatment. Results The levels of CD_4~＋T cells on 3,6,12 months after treatment were significantly higher than those before treatment（ P 0. 05）,moreover,which were obviously increased,along with the prolongation of time of therapy（ P 0. 05）. The levels of alanine transaminase after treatment were significantly lower than those before treatment（ P 0. 05）,however,the levels of serum creatinine were significantly lower than those before treatment（ P 0. 05）. Along with the prolongation of therapy time,the negative conversion rates of HIV RNA and HBV DNA were significantly increased（ P 0. 05）,furthermore,which reached 100% after 12-month treatment. Conclusion The first-line ART therapeutic schedule can effectively improve the immune function of patients with combined infection of HIV with HBV,improve patient ＇s liver function,and can effectively control HIV,HBV,with better tolerance,safety and reliability.

关 键 词：ART治疗方案 艾滋病 肝炎 乙型 治疗结果 

分 类 号：R512.91[医药卫生—内科学]