Gankyrin在胃癌及癌前病变中的表达及意义  

Expression of Gankyrin in gastric carcinoma and precancerious lesions and its significance

作　　者：戴观荣[1] 汤俊华[1] 丁洪亮[1] 赵卫国[1] 

机构地区：[1]广州军区总医院普外科,广东广州510010

出　　处：《局解手术学杂志》2016年第9期651-654,共4页Journal of Regional Anatomy and Operative Surgery

基　　金：广东省自然科学基金(S2013010011985)

摘　　要：目的探讨Gankyrin在胃癌及癌前病变(包括慢性萎缩性胃炎和胃黏膜上皮的异型增生)中的表达及其意义。方法采用免疫组织化学法检测Gankyrin在30例正常胃黏膜、60例慢性萎缩性胃炎、30例胃黏膜上皮异型增生和84例胃癌中的表达,同时分析Gankyrin表达和胃癌临床病理学特征的关系。结果 Gankyrin在正常胃黏膜、慢性萎缩性胃炎、胃黏膜异型增生和胃癌组织中均有不同程度的表达,而且表达差异具有统计学意义(P<0.05)。Gankyrin在胃癌中的表达与临床分期和转移相关,和患者的年龄、性别以及肿瘤的大小、组织学分级没有相关性。结论 Gankyrin不仅参与胃癌的早期发生,而且也参与胃癌的发展,Gankyrin有望成为胃癌诊断和防治的靶标。Objective To evaluate the expression of Gankyrin in gastric carcinoma and preancerious lesions （including chronic atrophic gastritis and gastric epithelial dysplasia）and its clinicopathological significance.Methods Immunohistochemical assay was performed to de-tect the Gankyrin expression in 30 casess of normal gastric mucosa,60 cases of chronic atrophic gastritis,30 cases of gastric epithelial dyspla-sia,and 84 cases of gastric carcinoma.Moreover,the relationship between Gankyrin expression and clinicopathological features of gastric car-cionma was analyzed.Results Gankyrin expression was detected in normal gastric mucosa,chronic atrophic gastritis,gastric epithelial dys-plasia,and gastric carcinoma tissues in varying degrees,and the difference of Gankyrin positive rates was significant in different gastric leions mentioned above （P 〈0.05）.The rate of Gankyrin expression in gastric carcinoma was significantly related with the clinical stage and metas-tasis.There’s no relationship between Gankyrin expression and the age,gender of patients,size,histologic grade of gastric carcinoma.Con-clusion Gankyrin participates in both the carcinogenesis and development of gastric carcinoma.Moreover,Gankyrin is a potential target for the diagnosis,prevention and treatment of gastric carcinoma.

关 键 词：胃癌 癌前病变 Gankyrin 慢性萎缩性胃炎 异型增生 

分 类 号：R735.2[医药卫生—肿瘤]