七氟醚的临床应用及代谢机制  

Clinical Application Status of Sevoflurane and Metabolic Mechanism

作　　者：王燕[1] 顾建腾[2] 

机构地区：[1]中国人民解放军总装备部后勤部无锡第一干休所,江苏无锡214065 [2]第三军医大学西南医院麻醉科,重庆400038

出　　处：《重庆理工大学学报（自然科学）》2016年第8期81-86,共6页Journal of Chongqing University of Technology：Natural Science

基　　金：国家自然科学基金资助项目(30600585)

摘　　要：七氟醚是一种卤族吸入式麻醉剂,具有诱导迅速、苏醒快、麻醉深度易于调节、对呼吸道刺激较小、循环抑制较轻、有一定的肌松作用等优点,目前广泛应用于临床麻醉,尤其在神经外科、心脏外科、小儿外科以及门诊手术中有显著优势。对其在临床麻醉中的应用进行了综述,并对其代谢机制进行了探讨。Sevofiurane is a type inhalation anesthetic with many advantages such as rapid induction, quick recovery, fine controllability on depth of anesthesia, gentle depression on circulation, low irritation on airway, muscle relaxation in some degrees and so on. Now sevoflurane has been used widely in clinical anesthesia. Its advantages are more obvious in neurosurgery, heart surgery, child surgery and the out-patient surgical operation. This article reviewed the application of sevoflurane in clinical anesthesia and explored its metabolic mechanism.

关 键 词：七氟醚 吸入 麻醉 CYP2E1 代谢机制 

分 类 号：R974.3[医药卫生—药品]