肠道菌群在中药研究中的应用  

Application of gut microbiota in research of Chinese medicines

作　　者：姜东京 张丽[1] 曹雨诞[1] 姚卫峰[1] 

机构地区：[1]南京中医药大学,江苏省中药资源产业化过程协同创新中心/中药资源产业化与方剂创新药物国家地方联合工程研究中心,江苏南京210023

出　　处：《中国中药杂志》2016年第17期3218-3225,共8页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金项目(30973940,81373972,80503250,81673599);江苏高校优势学科建设工程项目(ysxk-2014);江苏高校品牌专业建设工程项目(PPZY2015A070)

摘　　要：该文基于肠道菌群的生理功能,综述了近年来中药与肠道菌群相互作用的研究进展,包括有毒/刺激性中药对肠道菌群的失调影响,中药对肠道菌群失调的转归作用,肠道细菌对中药成分的代谢作用以及肠道菌群与宿主的共代谢作用等方面,对中药特定生物效应与肠道菌群结构及"肠道菌群-宿主共代谢"内源性代谢物间的联系进行思考和展望,旨在为基于肠道菌群探讨中药的生物学作用机制和物质基础,推动中药临床的安全有效应用提供新的策略。This article summarizes the research progress in recent years on interactions between Chinese medicines and gut microbi- ota based on the physiological functions of gut microbiota, including imbalance impacts of toxic/irritating Chinese medicines on gut mi- crobiota, prognosis effects of Chinese medicines on gut microbiota imbalance, metabolism effects of gut microbiota on Chinese medicine components, and co-metabolism effects between gut microbiota and host. We would think and prospect the specific biological effects of Chinese medicines, gut microbiota structures and the relations between endogenous metabolites from ＂gut microbiota and host co-metab- olism＂. All of these aim to investigate biological mechanisms and effective components of Chinese medicines based on gut microbiota and offer a new strategy for promoting safe and effective application of Chinese medicines.

关 键 词：肠道菌群 中药调控 成分代谢 肠道菌群-宿主共代谢 

分 类 号：R285[医药卫生—中药学]