ACS患者超敏-CRP和SYNTAX积分的相关性研究  

Correlation between high sensitive CRP level and SYNTAX score in patients with acute coronary syndrome

作　　者：王黎[1] 任品芳[1] 沈剑耀[1] 

机构地区：[1]中国医科大学绍兴医院(绍兴市中心医院)心血管内科,绍兴312030

出　　处：《新医学》2016年第8期553-557,共5页Journal of New Medicine

摘　　要：目的探讨超敏-CRP（hs-CRP）和SYNTAX积分所反映的ACS患者冠状动脉病变范围和严重程度的关系。方法选取ACS患者218例,根据SYNTAX积分将其分为低分组152例（1-22分）和中高分组66例（≥23分）,对患者的一般临床特征、hs-CRP等血液指标、冠状动脉造影特征等和SYNTAX积分的关系进行分析。结果 ACS患者中高分组的hs-CRP水平[（13.2±3.3）mg/L]高于低分组患者[（10.4±3.9）mg/L,P〈0.05]。中高分组的年龄、血糖、血清肌酐、总胆固醇、LDL、CK-MB、心肌肌钙蛋白T均高于低分组（P均〈0.05）,而中高分组的LVEF为（43.7±3.9）%,低于低分组的（53.7±6.8）%,2组比较差异有统计学意义（P〈0.05）。Logistic回归显示hs-CRP、年龄、LVEF、ST段抬高型心肌梗死、LDL、慢性完全闭塞性病变是SYNTAX中高分组的独立预测因子。结论 hs-CRP是SYNTAX积分所反映的ACS患者冠状动脉病变范围和严重程度的独立预测因子。Objective To explore the relationship between high sensitive CRP（ hs-CRP） and the extent and severity of coronary artery disease in patients with ACS reflected by SYNTAX score. Methods 218 cases of patients with ACS were selected. According to the SYNTAX score,the patients were divided into low SYNTAX score group（ 1-22 scores） including 152 cases of patients and intermediate-high SYNTAX score group（ ≥23 scores） including 66 cases of patients. The relationship between the clinic characteristics,blood biochemical parameters such as hs-CRP etc. coronary angiography features,etc. and SYNTAX score were analyzed. Results hs-CRP levels in intermediate-high SYNTAX score group were higher than those in low SYNTAX score group（ 13. 2 ± 3. 3 mg / L vs. 10. 4 ± 3. 9 mg / L,P〈0. 05）. At the same time,the age of patients,blood glucose,serum creatinine,total cholesterol,LDL,CK-MB,c Tn T in the intermediate-high SYNTAX score group were higher than that in the low SYNTAX score group（ all P〈0. 05）. However,the LVEF level of paitents in the intermediate-high SYNTAX score group was lower than that in the low SYNTAX score group（ 43. 7 ± 3. 9% vs. 53. 7 ± 6. 8%,P〈0. 05）. Logistic regression showed that hs-CRP levels,age,LVEF,STEMI,LDL,and CTO were independent predictors in SYNTAX score. Conclusions hs-CRP was an independent predictor of the extent and severity of coronary artery disease in patients with ACS,which was reflected by SYNTAX score.

关 键 词：超敏-C反应蛋白 急性冠状动脉综合征 SYNTAX积分 

分 类 号：R541.4[医药卫生—心血管疾病]