妊娠合并症与妊娠期接触化学毒物对出生缺陷影响的系统评价  

Effect of pregnancy complications and gestational exposure to toxic chemical on birth defect：a systematic ;evaluation

作　　者：岳书华[1] 万素馨[1] 

机构地区：[1]重庆三峡中心医院药学部,重庆市404000

出　　处：《中国基层医药》2016年第18期2724-2727,共4页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的：探讨妊娠合并症与妊娠期接触化学毒物对出生缺陷的影响，为制定最佳预防控制决策，实行有效的干预措施提供科学依据。方法根据纳入与排除标准进行文献评价与筛选，11篇文献纳入此次Meta 分析，累计病例3248例，对照5722例。由异质性检验结果决定采用固定或随机效应模型，并对合并结果进行χ2检验，同时应用漏斗图综合评估纳入文献的发表性偏倚。结果妊娠合并症的单因素分析合并效应值及其95％CI 为1．074（0．926～1．222），表明妊娠合并症是导致出生缺陷的危险因素；妊娠期接触化学毒物的单因素和多因素分析合并效应值及其95％CI 分别为1．426（1．147～1．704）、1．421（1．174～1．668），提示妊娠期接触化学毒物也是导致出生缺陷的危险因素。结论妊娠合并症和妊娠期接触化学毒物都是导致出生缺陷发生的危险因素，这为针对性预防出生缺陷的发生提供了参考。Objective To investigate the impact of pregnancy complications and gestational exposure to toxic chemical on birth defect,to provide scientific basis for effective intervention measures.Methods 11 studies were included,the quality evaluation and information extraction were carried out on the studies according to include and exclude standard.3 248 examples in case group and 5 722 examples in control group.Fixed or random effects model was used according to heterogeneity test results,and the combined result was analyzed by Chi -square test.The publi-cation bias of the studies was also evaluated.Results The combined results of single factor analysis of pregnancy complications was 1.074（0.926 -1.222）,showed that pregnancy complications were risk factors of birth defects.The combined results of single factor and multiple factors analysis of gestational exposure to toxic chemical were 1.426 （1.147 -1.704）,1.421（1.174 -1.668）,also showed that gestational exposure to toxic chemical was a risk factor of birth defects.Conclusion Pregnancy complications and gestational exposure to toxic chemical are risk factors of birth defects,this targeted provides reference to birth defects prevention.

关 键 词：出生缺陷 妊娠合并症 妊娠期接触化学毒物 META 分析 

分 类 号：R714.25[医药卫生—妇产科学] R714.5[医药卫生—临床医学]