纳洛酮联合氨茶碱治疗小儿急性呼吸衰竭的临床疗效观察  

Clinical efficacy of naloxone plus aminophylline in the treatment of children with acute respiratory failure

作　　者：王利珍[1] 龙欣欣[1] 毕玉娜[1] 

机构地区：[1]山东省交通医院儿科,山东省济南250031

出　　处：《中国基层医药》2016年第18期2825-2828,共4页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的：观察纳洛酮联合氨茶碱治疗小儿急性呼吸衰竭的临床疗效。方法将72例急性呼吸衰竭患儿采用数字表法随机分为研究组和对照组，其中36例的研究组采用纳洛酮联合氨茶碱治疗，36例的对照组则采用常规疗法，并对比两组临床疗效。结果研究组治疗总有效率为91．67％，与对照组的66．67％相比效果更为显著（χ2＝6．82，P ＜0．05）；在各项血气指标的改善效果比较上，研究组动脉血氧分压为（67.51±4．11）mmHg，高于对照组的（61．03±4．08）mmHg，差异有统计学意义（t ＝2．64，P ＜0．05）；血氧饱和度为（93．55±8．05）％，与对照组（79．62±10．22）％相比明显升高，差异有统计学意义（t ＝2．29，P ＜0.05）；动脉血二氧化碳分压为（69．03±5．71）mmHg，高于对照组的（61．52±4．09）mmHg，差异有统计学意义（t ＝2.22，P ＜0．05）。研究组不良反应发生率为2．78％，低于对照组的22．22％，两组差异有统计学意义（χ2＝6.22，P ＜0．05）。结论纳洛酮联合氨茶碱应用于小儿急性呼吸衰竭的临床治疗，可获得理想的治疗效果，不仅能够有效改善患儿的血气指标，且无明显的不良反应情况，药物安全性较高，值得推广。Objective To observe the clinical efficacy of naloxone plus aminophylline in the treatment of children with acute respiratory failure.Methods 72 patients with acute respiratory failure were randomly divided into the study group and the control group.36 cases in the study group were given naloxone plus aminophylline therapy, 36 cases of the control group received conventional therapy.And the clinical efficacy was compared.Results The total effective rate of the study group was 91.67%,which was significantly higher than 66.67% of the control group （χ2 =6.82,P 〈0.05）.In the comparison of the effect of improving blood indicators,arterial blood pressure of the study group was （67.51 ±4.11）mmHg,which was significantly higher than （61.03 ±4.08）mmHg in the control group （t =2.64,P 〈0.05）.The oxygen saturation of the study group was （93.55 ±8.05）%,which was significantly higher than （79.62 ±10.22）% of the control group （t =2.29,P 〈0.05）.The arterial carbon dioxide partial pres-sure of the study group was （69.03 ±5.71）mmHg,which was also higher than （61.52 ±4.09）mmHg of the control group （t =2.22,P 〈0.05）.The incidence rate of adverse reactions of study group was 2.78%,which was lower than 22.22% in the control group （χ2 =6.22,P 〈0.05）.Conclusion Naloxone plus aminophy -lline used in children with acute respiratory failure obtain the desired therapeutic effect,not only can effectively improve blood indicators of children,and without significant adverse reactions,drug safety is high,it is worthy of promoting.

关 键 词：呼吸衰竭 纳洛酮 氨茶碱 

分 类 号：R725.6[医药卫生—儿科]