新型刷型固定相的制备与评价  

Preparation and Evaluation of New Brush Chiral Stationary Phase

作　　者：李杨[1] 李连杰[2] 蒋登高[2] 朱进科 

机构地区：[1]河南省食品药品检验所,河南郑州450003 [2]郑州大学化工与能源学院,河南郑州450001

出　　处：《化学试剂》2016年第9期829-833,共5页Chemical Reagents

基　　金：河南省科技攻关资助项目(092102210177)

摘　　要：以硅胶为载体、β-(3,4-环氧环己烷)乙基三甲氧基硅烷为间隔臂、常用药物辛伐他汀为手性源,采用键合法制备出了新型刷型手性固定相(CSP),对安息香、钙离子拮抗剂和二苯丁酮等对映体进行了手性拆分测试,并以"三点作用"理论从流动相组成与分子结构等方面对其分离机理进行了探讨。良好的拆分结果证明,辛伐他汀以其多个手性中心特点在手性固定相的研制中具有较好的开发潜力。Based on silica gel as the carrier,β-（3,4-epoxy cyclohexane） ethyl trimethoxysilane as the spacer and simvastatin as chiral source, new brush chiral stationary phase was synthesized. The resultant CSP provide effective separation of benzoin, calci- um antagonists and 1,2-diphenyl-1-butanone. The effects of mobile phase composition and molecular structure on enantioseparation were investigated by ＂Three-point rule＂. The experimental results indicated that simvastatin with multi-chiral centers had a huge potential for development of chiral stationary phase.

关 键 词：辛伐他汀 手性固定相 刷型 拆分 

分 类 号：O657.7[理学—分析化学]