雷公藤多苷片联合抗组胺药治疗慢性荨麻疹系统评价  

System Evaluation of Glucoside Tripterygium Total Combined with Antihistamine Medicine for Chronic Idiopathic Urticaria

作　　者：温雯婷 黄晶晶[1] 王鹏丽[1] 虞舜[1] 

机构地区：[1]南京中医药大学,江苏省中医药防治肿瘤协同创新中心,江苏南京210023

出　　处：《中国中医药信息杂志》2016年第10期46-50,共5页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：国家中医药管理局中医药标准化项目(ZYYS-2011〔0002〕);国家中医药管理局中医药科学技术研究专项(2009zx07-15)

摘　　要：目的系统评价雷公藤多苷片(GTT)联合抗组胺药治疗慢性荨麻疹(CIU)的有效性和安全性。方法计算机检索中国知识资源总库(CNKI)、中文科技期刊数据库(VIP)、中国学术期刊数据库(万方数据)、中国生物医学文献数据库(CBM)、Embase、Pub Med、Cochrane Library中GTT联合抗组胺药治疗CIU的临床随机和半随机对照试验相关文献。2名研究者独立进行数据筛选和资料提取后,按照Cochrane系统评价手册5.1.0偏倚风险评估工具评价纳入文献的质量,采用Rev Man5.3软件进行Meta分析。结果共纳入21篇文献,2194例受试者。Meta分析显示,与对照组比较,GTT联合抗组胺药治疗CIU可明显提高有效率[RR=1.33,95%CI(1.26,1.40),P<0.000 01]、明显降低复发率[RR=0.45,95%CI(0.33,0.62),P<0.000 01],不良反应发生率差异无统计学意义。结论 GTT联合抗组胺药治疗CIU疗效确切,且相对安全。临床是否应常规采用GTT联合抗组胺药治疗CIU,尚需通过大样本、多中心、高质量的临床随机对照试验来验证。Objective To systematically evaluate the effectiveness and safety of glucoside tripterygium total（GTT） combined with antihistamine medicine for chronic idiopathic urticaria（CIU）. Methods All randomized or semi-randomized controlled trials（RCTs or semi-RCTs） of GTT in treating CIU were collected from CNKI, VIP, Wan Fang Data, CBM, Embase, Pub Med and Cochrane Library clinical controlled trials database. After two researchers conducted screening and data extraction independently, the quality of the included literature research was evaluated according to the risk of bias tool described in the Cochrane Handbook version 5.1.0, and then Rev Man 5.3 was used to undertake Meta analysis. Results A total of 21 articles about RCTs and semi-RCTs were obtained, including 2194 patients. Meta analysis indicated that GTT combined with antihistamine medicine treatment showed higher effective rates compared with the control group [RR=1.33, 95%CI（1.26, 1.40）, P〈0.000 01], with obviously lower recurrence rate [RR=0.45, 95%CI（0.33, 0.62）, P0.000 01]. There was no statistical significance in adverse reactions. Conclusion GTT combined with antihistamine medicine for CIU has definite efficacy, and is relatively safe. Whether apply GTT combined with antihistamine medicine for CIU should be verified through randomized controlled trial with large-scale samples, multiple centers and high quality.

关 键 词：雷公藤多苷片 慢性荨麻疹 系统评价 META分析 

分 类 号：R275.982.4[医药卫生—中西医结合] R2-05[医药卫生—中医皮科]