硫酸特布他林雾化液在儿童肺功能支气管舒张试验中的运用研究  

Study on the Application of Terbutaline Sulphate Solution for Nebulization in Children's Pulmonary Function Bronchodilation Test

作　　者：杜继宇[1] 李艳[1] 刘蓉[1] 林媛媛[1] 王小双[1] 扬进宇 

机构地区：[1]绵阳市中心医院儿科,四川绵阳621000

出　　处：《四川医学》2016年第9期993-996,共4页Sichuan Medical Journal

摘　　要：目的：评价用硫酸特布他林雾化液进行儿童肺功能支气管舒张试验的敏感性、特异性及安全性。方法对2016年3月至2016年6月在我院门诊及住院部就诊的反复喘息临床怀疑儿童支气管哮喘的患儿80例,随机分为试验组和对照组,试验组用AstraZeneca AB生产的硫酸特布他林雾化液：体质量〈20kg,1mL（2．5mg特布他林）＋生理盐水1mL,体质量〉20kg 2mL（5．0mg 特布他林）；对照组用深圳大佛药业有限公司生产的硫酸沙丁胺醇雾化溶液：6~8岁0．5mL （2．5mg沙丁胺醇）＋生理盐水1．5mL,〈12岁0．75mL（3．75mg沙丁胺醇）＋生理盐水1．25mL,〉12岁1mL（5．00mg沙丁胺醇）＋生理盐水1mL。用德国百瑞牌空气压缩泵雾化吸入,吸入后15min重复测FEV 1,以FEV 1改善率增加≥12%为肺功能支气管舒张试验阳性；吸入支气管舒张剂前及试验结束后即刻记录患儿呼吸、心率、氧饱和度,试验结束还需观察患儿口咽刺激感、头晕头痛、骨骼肌震颤、心悸,并行心电图及血压监测。结果试验组及对照组患儿吸入支气管舒张剂后15min肺功能明显改善,与试验前肺功能比较差异有统计学意义（P〈0．05）；试验组患儿40例,支气管舒张试验阳性36例,阳性率为90．00%；对照组患儿40例,支气管舒张试验阳性37例,阳性率为92．50%,差异无统计学意义（ P〉0．05）。试验组患儿40例不良反5例,不良反应率12．50%；对照组40例不良反应10例,不良反应率25．00%；两组患儿均无心律紊乱、低血压、一过性低氧血症、皮疹等情况发生。两组患儿不良反应发生率差异无统计学意义（ P〉0．05）。结论用硫酸特布他林雾化液行儿童肺功能支气管舒张试验敏感性特异性强、安全性好,可在儿童肺功能支气管舒张试验中广泛运用。Objective To evaluate the sensitivity,specificity and safety of the application of the terbutaline sulphate solu-tion for nebulization in children’s pulmonary function bronchodilation test. Methods 80 cases of children with clinical suspicion of bronchial asthma because of repeated wheezing in our hospital outpatient and inpatient treatment,March 2016 to June 2016,were randomly divided into experimental group and control group,Test group using terbutaline sulphate solution for nebulization AB As-traZeneca,weight 〈20kg,1mL（2. 5 mg of terbutaline） ＋ normal saline 1mL,weight〉20kg 2mL（5mg of terbutaline）;the control group using salbutamol solution Shenzhen Dafo Pharmaceutical Co. ,Ltd. production：6-8 years 0. 5mL（2. 5 mg salbutamol） ＋ nor-mal saline 1. 5mL,aged 9-12 0. 75 ml（3. 75 mg salbutamol） ＋normal saline 1. 25mL,〉12 years old 1mL（5. 00mg salbutamol） ＋normal saline 1mL. The two groups were inhaled drug using German production Braim brand air compressor pump,15 minutes after repeated measurements of FEV 1 ,FEV 1 increased more than 12% improvement rate of lung function with positive bronchodilation test. Breathing,heart rate and oxygen saturation were recorded before and after the end of the test,in the end of the test to observe patients with oropharyngeal irritation, dizziness, headache, muscle tremor, palpitations, and monitor ECG and blood pressure. Re-sults 15 minutes after inhalation of bronchodilators,test group and control group pulmonary function improved significantly. ,by t test,compared with the test before the lung function has a significant difference（P〈0. 05）. In 40 cases of test group,the positive rate of bronchial dilation test was 36 cases,the positive rate was 90%;in 40 cases of control group,the positive rate of bronchial di-lation test was 37 cases,the positive rate was 92. 50%, the difference was not statistically significant（P〉0. 05）. Adverse reaction rate was 5 in the test group,and the adverse reaction rate was 12. 50%;in the control group

关 键 词：支气管舒张试验 硫酸特布他林雾化液 支气管哮喘 儿童 

分 类 号：R725.6[医药卫生—儿科]