塞来昔布超前镇痛对脊柱手术患者术后PCA镇痛效果的影响  

Influence of Celecoxib on the Preemptive Analgesia Effect of PCA Analgesia in Patients after Spinal Surgery

作　　者：何崎[1] 吴文知[2] 

机构地区：[1]成都体育学院附属体育医院麻醉科,四川成都610041 [2]四川省骨科医院,四川成都610041

出　　处：《四川医学》2016年第9期1021-1023,共3页Sichuan Medical Journal

摘　　要：目的观察塞来昔布超前镇痛对脊柱手术患者术后镇痛效果的影响。方法 180例择期脊柱手术患者随机分为静脉PCA组(P组)及塞来昔布超前镇痛复合静脉PCA组(CP组),CP组术前1h口服塞来昔布,所有患者术后使用静脉自控镇痛泵。记录术后1h、6h、12h、24h、48h静止、运动VAS评分,Ramsay镇静评分,术后麻醉恢复时间、患者满意度及不良反应发生率等。结果 CP组术后1h、6h、12h静止VAS评分明显低于P组,CP组术后1h、6h运动VAS评分明显低于P组,两组患者术后各观察时点镇静评分、术后麻醉恢复时间、患者满意度、补充镇痛药物使用率差异无统计学意义(P>0.05)。结论塞来昔布术前单次口服超前镇痛联合术后PCA镇痛可明显降低脊柱手术患者术后24h内疼痛,镇痛效果优越、平稳、安全,推荐临床使用。Objective To observe the effect of celecoxib on the analgesic effect of preemptive analgesia in patients after spinal surgery. Methods 180 patients undergoing elective spinal surgery were randomly divided into intravenous PCA group （ P group） and celecoxib preemptive analgesia combined with intravenous PCA group（ CP Group） . Patients in the CP group were orally administered celecoxib 1 h before surgery,and all patients were used intravenous self-controlled analgesia pump after operation. The stillness and movement VAS score of 1h,6h,12h,24h,48h after surgery,the Ramsay sedation score,the postoperative anesthesia recovery time,the patient satisfaction and the adverse reaction rate were recorded. Results The 1h,6h,12h stillness VAS scores after surgery in CP group were significantly lower than those in P group;The 1h,6h movement VAS scores after surgery in CP group were significantly lower than those in P group. And there were no significant differences in the sedation score,the postoperative an-esthesia recovery time,the patient satisfaction,and the adding analgesic drug use rate in both two groups of patients after each ob-servation point. Conclusion A single oral dose of celecoxib before operation and preemptive analgesia combined with postopera-tive analgesia can significantly reduce the pain of patients within 24 hours after the spinal surgery,and the analgesic effect is supe-rior,stable and safe,which is recommended for clinical use.

关 键 词：塞来昔布 超前镇痛 脊柱手术 术后镇痛 

分 类 号：R614[医药卫生—麻醉学]