住院2型糖尿病患者胆囊结石危险因素的分析  

Risk factors for gallstone disease in hospitalized patients with type 2 diabetes

作　　者：石威[1] 牛旭[1] 孙海涛[1] 韩威[1] 纪智礼[1] 

机构地区：[1]首都医科大学附属北京潞河医院普外科,北京101149

出　　处：《临床和实验医学杂志》2016年第18期1852-1854,共3页Journal of Clinical and Experimental Medicine

摘　　要：目的研究住院2型糖尿病患者合并胆囊结石的危险因素。方法选取2015年1月至2016年6月住院2型糖尿病患者1 562例,按是否合并胆囊结石分为胆囊结石组和对照组,比较两组的肝功能、血脂及血常规等指标,采用二分类的logistic回归分析胆囊结石危险因素。结果胆囊结石组的平均年龄(67.21±11.589岁)大于对照组(60.19±13.468岁),胆囊结石组低密度脂蛋白胆固醇(LDL-C)的平均值(2.02±1.017 mmol/L)显著低于对照组(3.61±1.025 mmol/L),高密度脂蛋白胆固醇与低密度脂蛋白胆固醇比值(HDL-C/LDL-C)(0.35±0.133)显著低于对照组(0.39±0.192),中性粒细胞和淋巴细胞比值(NLR)的平均值(2.87±2.082)显著高于对照组平均值(2.43±1.875),尿酸(UA)的平均值(270.98±78.742 mmol/L)显著低于对照组(287.87±96.814 mmol/L),差异均有统计学意义(P<0.05)。二分类的logistic回归分析危险因素,年龄(P<0.001,OR=1.047)为危险因素,HCT(P=0.004,OR=0.005)、HDL-C/LDL-C的比值为保护性因素(P=0.001,OR=0.073)。结论在2型糖尿病患者中,随着年龄的增加,胆囊结石的患病风险增加,高LDL-C,低HDL-C可以促进胆囊结石的发生,HCT为胆囊结石的保护性因素。Objective Aim To study the risk factors of patients with type 2 diabetes mellitus complicated with gallstone. Methods We selected hospital type 2 diabetes patients 1562 from January 2015 to June 2016. All these patients were divided into gallstone group and control group according to whether or not with gallbladder stone, compared with two groups of liver function, lipid and blood routine indexes, binary logistic regression analysis of risk factors of gallstone disease. Results The mean age （67. 21 ± 1 1 . 5 8 9 ） in the group of gallstone was higher than that in the control group （60.19 ± 13.468） . Low density lipoprotein cholesterol （ LDL - C） average （2. 02 ± 1.017） mmol/L was significantly higher than the average value of LDL - C （3. 61 ± 1. 025） mmol/L of the control group. High density lipoprotein cholesterol to low density lipoprotein cholesterol （HDL - C/LDL - C） （0.35±0.133） ratio was significantly lower than the control group （0. 39 ± 0. 192）. Neutrophils to lymphocyte ratio （NLR） average （2. 87±2. 082） was significantly higher than the control group average （2.43± 1.875） （ P =0.020）. Uricacid （UA） average （270. 98 ± 78 . 742） mmol/L D was significantly lower than that of the control group UA level Mean （287. 87 ± 96. 814） mmol/L （ P = 0.025）. Binary logistic regression analysis of risk factors, age （ P 〈 0 . 0 0 1 , OR=1.047） as a risk factor, HCT （ P = 0 . 0 0 4 , OR = 0 . 0 0 5 ） is a protective factor, HDL / LDL ratio is a protective factor （ P = 0 . 0 0 1 , OR = 0. 073）. Conclusion In patients with type 2 diabetes, with the increase of age, gallstone risk increased, high LDL - C, low HDL - C can promote the occurrence of gallstone and HCT were the protective factors of gallstone.

关 键 词：2型糖尿病 胆囊结石 危险因素 

分 类 号：R587.1[医药卫生—内分泌]