联苯苄唑与硝酸咪康唑治疗婴幼儿皮肤念珠菌病疗效比较  

An Effect Comparison Between Bifonazole and Miconazole Nitrate to Treat Infant Skin Candidiasis

作　　者：罗青华[1] 周茂松[1] 

机构地区：[1]云南省西双版纳州人民医院皮肤科,云南景洪666100

出　　处：《内蒙古医学杂志》2016年第5期525-527,共3页Inner Mongolia Medical Journal

摘　　要：目的探讨联苯苄唑与硝酸咪康唑治疗婴幼儿念珠菌病疗效差异。方法以联苯苄唑(1%)和硝酸咪康唑(2%)治疗婴幼儿皮肤念珠菌病各30例,两种药物每日外用2次,疗程为2周,记录并比较两组患者用药1、2周时的疗效及不良反应。结果用药1周时联苯苄唑组治愈19例(63.3%),硝酸咪康唑组治愈10例(33.3%);两组有效率无明显统计学差异(P>0.05)。用药2周时,两组治愈率差异进一步扩大,联苯苄唑组治愈23例(76.7%),硝酸咪康唑组为11例(36.7%),两组有效率出现明显统计学差异(P<0.05),联苯苄唑组有效率(93.3%)明显高于硝酸咪康唑组(70.0%)。两组患者未见明显副作用。结论治疗婴幼儿皮肤念珠菌病联苯苄唑有效率高于硝酸咪康唑。Objective To analyze differences of curative effects between bifonazole and miconazole nitrate to treat infant skin candidiasis. Methods Treating infant skin candidiasis with bifonazole （1% ） and miconazole nitrate（2 % ） for 30 patients respectively. Two drugs for external use only 2 times a day, course of treatment for 2 weeks, recording and compared curative effect and adverse reactions of the two kinds of drugs at one and two weeks. Results At one week, bifonazole cured 19 cases （63.3 % ）, miconazole nitrate group of 10 cases were cured（33.3 %）. There was no significant statistical difference between the two groups（ P 〉 0.05）. At two week, effective rate of bifonazole（93.3 % ） was obviously higher than miconazole nitrate（70.0 %, P 〈 0.05）. There were no obvious side effects between the two groups. Conclusions Effective rate of bifonazole to infant skin candidiasis was higher than miconazole nitrate.

关 键 词：念珠菌 婴幼儿 联苯苄唑 硝酸咪康唑 

分 类 号：R756.5[医药卫生—皮肤病学与性病学]