辛伐他汀治疗COPD合并肺动脉高压患者疗效观察  

Clinical Efficacy of Simvastatin in Treatment of COPD Complicated with Pulmonary Hypertension

作　　者：丁彦[1] 

机构地区：[1]赣南医学院第一附属医院呼吸内科,江西赣州341000

出　　处：《今日药学》2016年第8期606-608,共3页Pharmacy Today

摘　　要：目的探究辛伐他汀治疗慢性阻塞性肺疾病（COPD）合并肺动脉高压患者的临床疗效。方法将2012-01~2015-12本院收治的100例慢性阻塞性肺疾病合并肺动脉高压患者随机分为2组,每组50例。对照组采取常规治疗方案,观察组在常规治疗方案的基础上加用辛伐他汀。治疗3个月和6个月后比较2组患者的临床总有效率,并对2组患者治疗前后的肺通气功能、肺动脉收缩压、动脉血氧分压及动脉二氧化碳分压进行比较。结果与对照组相比,观察组治疗3个月后、6个月后的临床总有效率均明显更高（P〈0.05）。与治疗前相比,治疗后3个月和6个月,2组患者的肺通气功能、肺动脉收缩压、动脉血氧分压、动脉二氧化碳分压等指标均显著改善（P〈0.05）,但在治疗后,观察组的各项指标较对照组均明显更优（P〈0.05）。结论在慢性阻塞性肺疾病合并肺动脉高压的临床治疗中,采用辛伐他汀治疗具有显著的疗效,能够有效改善患者的肺通气功能,控制肺动脉压,改善血氧状况。OBJECTIVE To explore the clinical efficacy of simvastatin in the treatment of chronic obstructive pulmonary disease （COPD） complicated with pulmonary hypertension. METHODS From January 2012 to December 2015, 100 cases with COPD combined with pulmonary hypertension were treated in the First Affiliated Hospital of Gannan Medical College,they were elected as the research object, and were randomly divided into 2 groups,50 cases in each group. The control group was treated with routine treatment, and the observation group was treated with simvastatin on the basis of conventional therapy. The clinical total effective rate between the 2 groups were eompared;and the pulmonary ventilation function, puhnonary artery systolic pressure, arterial oxygen partial pressm＇e and arterial carbon dioxide partial pressure betore and atier treatment were compared between the 2 groups. RESULTS Compared with the control group, the total effective rate of the observation group after 3 months and 6 months of treatment were significantly higher （P〈0.05）. Compared with before treatment, pulmonary ventilation function and pulmonary artery systolic pressure, arterial oxygen hraneh pressure,arterial carbon dioxide partial pressure after 3 months and 6 months of treatment index in the 2 groups were significantly improved after treatment （P〈0.05）. But after treatment, the improvement of these indicators in the observation group was significantly better than that in the control group （P〈 0.05）. CONCLUSION The clinical efficacy of simvastatin in the treatment of COPD complicated with pulmonary hypertension is remarkable, can effectively improve the patients＇ pulmonary function, effectively control puhnonary arterial pressure,and improve blood oxygen condition. It is recommended for clinical physicians to promote and use.

关 键 词：慢性阻塞性肺疾病 肺动脉高压 辛伐他汀 

分 类 号：R97[医药卫生—药品]