中药调节心肌缺血再灌注损伤的活性成分及作用机制  

Chinese Medicine in Prevention and Treatment of Myocardial Ischemia Reperfusion Injury

作　　者：张宇[1] 李建锋[2] 单红燕 伏瑶 赵启韬[1] 

机构地区：[1]山东中医药大学中医学院,山东济南250355 [2]山东中医药大学药学院,山东济南250355

出　　处：《辽宁中医杂志》2016年第8期1709-1713,共5页Liaoning Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金资助项目(81173164,81573852)

摘　　要：近10年来,新发现16种中药对心活性成分肌缺血再灌注损伤有明确保护作用。这些成分是从23种中草药中分离纯化出来的,多数是具有环状结构的极性分子,具强氧化或强还原性。这16种成分通过调控相关的信号通路,从而发挥清除氧自由基、抑制钙超载及心肌细胞凋亡、干预炎症反应、保护血管内皮功能等作用,从而达到抗心肌缺血再灌注的效果。文章全面概述了这16种成分的分子结构、理化性质、源自何种中草药,以及它们发挥心肌缺血再灌注保护作用的机制,系统总结了10年来中药"补气活血、开胸除痹"的物质基础及作用机制研究进展。In the past 10 years,the newly discovered 16 kinds of Chinese herbal medicine on ischemia reperfusion injury of heart muscle activity components have a clear protective effect. These ingredients are from 23 kinds of herbs in the separation and purification of the most polar molecules which have a ring structure,with strong oxidation or strong reduction. These 16 components,by adjusting the control signal pathway,scavenging oxygen free radicals or calcium overload,inhibiting the apoptosis of myocardial cells,intervening the inflammation and protecting vascular endothelial function,so as to achieve the anti myocardial ischemia reperfusion effect. This paper summarizes the molecular structure of the 16 components’ physical and chemical propertiesand the mechanism of myocardial ischemia and reperfusion protection system and summed up the 10 years of traditional Chinese medicine of invigorating Qi and promoting blood circulation,opening the chest in progress on substance basis and mechanism study of Bi.

关 键 词：心肌缺血再灌注损伤 中药活性成分 生物碱 多糖 黄酮 机制 

分 类 号：R962[医药卫生—药理学]