急性心肌梗死PCI术前静脉注射丹红注射液联合硝酸甘油的临床研究  

Clinical study of intravenous injection of Danhong Injection combined with nitroglycerin before PCI in patients with acute myocardial infarction

作　　者：黄梦照[1] 

机构地区：[1]广西壮族自治区百色市人民医院心血管内科,广西百色533000

出　　处：《中国医药导报》2016年第24期152-155,共4页China Medical Herald

摘　　要：目的探讨急性心肌梗死经皮冠状动脉介入治疗（PCI）术前静脉注射丹红注射液联合硝酸甘油的临床疗效。方法纳入百色市人民医院于2013年4月～2015年4月期间接受诊治的发病12h内行急诊PCI治疗的急性心肌梗死患者100例，按照随机数字表法分为对照组50例与观察组50例。对照组于PCI术前给予硝酸甘油。观察组在硝酸甘油基础上静脉注射丹红注射液。比较两组患者血清超敏C-反应蛋白和白介素-10水平，血浆MMP-9和BNP水平及左室功能指标水平变化。结果两组术后3d血清超敏C-反应蛋白和白介素-10水平较治疗前明显减少（P〈0．05）；观察组术后3d血清超敏C-反应蛋白和白介素-10水平明显低于对照组（P〈0．05）；两组术后3d血浆BNP水平较治疗前明显减少（P〈0．05）；观察组术后3d血浆MMP-9水平较治疗前明显减少（P〈0．05），而对照组比较差异无统计学意义（P〉0．05）；观察组左心室射血分数（LVEF）明显高于对照组（P〈0．05），左室舒张末期内径（LVEDD）和左房收末内径（LAD）明显低于对照组（P〈0．05）。结论急性心肌梗死PCI术前静脉注射丹红注射液联合硝酸甘油的临床效果明显，值得临床进一步研究。Objective To investigate the clinical effect of Danhong Injection combined with nitroglycerin intravenous injection to acute myocardial infarction （AMI） before PCI. Methods 100 AMI patients in 12 h treated by PCI from April 2013 to April 2015 were randomized divided into the control group and observation group, with 50 cases in each group. The control group was given nitroglycerin before PCI, and the observation group was given Danhong Injection and Nitroglycerin Injection. The parameters of serum high sensitive C-reactive protein and interleukin -10 level, plasma MMP-9 and BNP levels and left ventricular function index level in two groups were compared. Results After 3 days, serum high-sensitivity C-reactive protein and interleukin-10 levels of two groups were significantly lower than before （P 〈 0.05）; the serum high-sensitivity C-reactive protein and interleukin-10 levels of observation group were significantly lower than the control group （P 〈 0.05）; the plasma BNP level of the two groups was significantly decreased after treatment （P 〈 0.05）; the MMP-9 level in the observation group was significantly decreased （P 〈 0.05）, while the control group had no significant difference （P 〉 0.05）; the content of LVEF in the observation group was sig- nificantly higher than control group （P 〈 0.05）, LVEDD and LAD were significantly lower than those in the control group （P 〈 0.05）. Conclusion The clinical effect of intravenous injection of Dan Hong injection combined with nitroglycerin before PCI in AMI patients is obvious, which is worthy of further study.

关 键 词：急性心肌梗死 PCI 丹红注射液 硝酸甘油 

分 类 号：R542.2[医药卫生—心血管疾病]