AP-2α、Bcl-2及C-myc在重度子痫前期患者胎盘组织中的表达及意义  

Expression and significance of AP-2α,Bcl-2 and C-myc in severe preeclampsia

作　　者：张玲[1] 曾宪旭[2] 张展[3] 常爱民[3] 

机构地区：[1]郑州大学第三临床学院妇产科,450052 [2]郑州大学第三临床学院妇产科病理科,450052 [3]郑州大学第三临床学院妇产科检验科,450052

出　　处：《中国实用医刊》2016年第16期28-30,F0004,共4页Chinese Journal of Practical Medicine

摘　　要：目的：探讨转录因子激活蛋白-2α（ AP-2α）与B淋巴细胞瘤-2基因（ Bcl-2）、C-myc在重度子痫前期胎盘组织中的表达及其意义。方法采用免疫组化法及实时荧光定量-PCR（ RT-PCR）的方法，检测重度子痫前期组胎盘组织及正常对照组胎盘组织中AP-2α及Bcl-2、C-myc蛋白及mRNA的表达。结果重度子痫前期组胎盘组织中AP-2α蛋白明显高于正常对照组（P﹤0.05），Bcl-2和C-myc蛋白表达明显低于正常对照组（P﹤0.05）；重度子痫前期组胎盘组织中AP-2α mRNA明显高于正常对照组（P﹤0.05），C-myc和Bcl-2 mRNA表达明显低于正常对照组（ P﹤0.05）。结论 AP-2α和Bcl-2、C-myc在重度子痫前期患者胎盘组织中的差异表达参与重度子痫前期的病理生理过程。Objective To investigate the role of AP-2α,Bcl-2 and C-myc proein and mRNA in severe preeclampsia. Methods The expression of AP-2α,Bcl-2 and C-myc in placental tissues in se-vere preeclamptic pregnancies and normotensive pregnancies were analyzed by using immunohistochemis-try and RT-PCR. Results The positive expression of AP-2α for placenta trophoblast in severe pre-eclampsia was significantly higher than that in control group（ P﹤0. 05 ）,while the positive expressions of Bcl-2 and C-myc were significantly lower than those in control group（ P﹤0. 05 ）. The expression of AP-2αmRNA for placenta tissue in severe preeclampsia was significantly higher than that in control group （ P﹤0. 05 ）,while the expressions of Bcl-2 and C-myc mRNA were significantly lower than those in con-trol group（ P﹤0. 05 ）. Conclusions AP-2αand Bcl-2 ,C-myc participate in the pathological process of preeclampsia.

关 键 词：转录因子激活蛋白-2α B淋巴细胞瘤-2基因 重度子痫前期 

分 类 号：R285.5[医药卫生—中药学]