白簕提取物抑制痤疮丙酸杆菌及美白活性研究  

Study on Antimicrobial Activity Against Propionibacterium Acnes and Whitening Effect of Extract of Eleutherococcus Trifoliatus in Vitro

作　　者：劳景辉[1,2] 潘超美[1] 喻勤 倪庆桂 孙忠伟 郁晓艺 

机构地区：[1]广州中医药大学,广东广州510006 [2]完美(中国)有限公司,广东中山528402

出　　处：《中国现代中药》2016年第9期1120-1124,共5页Modern Chinese Medicine

摘　　要：目的:对白簕提取物的抑制痤疮丙酸杆菌和美白活性进行研究,评价白簕提取物的生物活性强弱。方法:以测定最小抑菌浓度(MIC)来评价白簕提取物抑制痤疮丙酸杆菌生长的活性;以抑制B16黑色素瘤细胞内酪氨酸酶能力,测定其美白活性。结果:白簕醇提物和水提物抑制痤疮丙酸杆菌的MIC值分别为2.5 mg·mL^(-1)和5 mg·mL^(-1);白簕水提物对酪氨酸酶抑制活性较好,但醇提物未发现该活性。结论:白簕醇提物具有良好的抑制痤疮丙酸杆菌活性,而水提物的活性则表现在抑制酪氨酸酶中。Objective： Antimicrobial activity against Propionibacterium acnes and whitening effect of extract of Eleutherococcus trifoliatus were studied to assay the bioactivities. Methods： Antimicrobial activity against P. acnes was evaluated by MIC. Whitening effect was tested by the tyrosinase inhibitory activity in B16 cell. Results： The MIC of ethanol extract and water extract were 2. 5 mg·mL^-1, 5 mg·mL^-1, respectively. Water extract had good tyrosinase inhibitory activity, while ethanol extract showed no effect. Conclusion： Ethanol extract had stronger activity than water extract in antimicrobial against P. acnes, but water extract had good tryosinase inhibitory activity.

关 键 词：白筋 提取物 抑制痤疮丙酸杆菌 美白活性 

分 类 号：R758.733[医药卫生—皮肤病学与性病学]