2型糖尿病患者高甘油三酯血症-腰围表型与糖尿病肾脏病的相关性  

Association of diabetic kidney disease with hypertriglyceridaemic-wasit phenotype in patients of type 2 diabetes mellitus

作　　者：郝慧瑶[1] 张芳[1] 周静[1] 陈彦霞[1] 王静[1] 郝咏梅[1] 

机构地区：[1]河北医科大学第二医院内分泌科,河北石家庄050000

出　　处：《临床荟萃》2016年第9期964-967,共4页Clinical Focus

基　　金：河北省自然科学基金资助项目面上项目(512015206506)

摘　　要：目的探讨2型糖尿病（T2DM）患者中高甘油三酯血症-腰围表型（HTWC表型）与糖尿病肾脏病（DKD）的关系。方法将753例T2DM患者以血甘油三酯≥1.7mmoL/L、腰围男性≥85cm或女性≥80cm为切点,分为甘油三酯和腰围正常组、单纯高甘油三酯组、单纯腹型肥胖组、高甘油三酯血症-腰围表型（HTWC）组,比较4组间DKD的发生率及各生化指标,并进行Logistic回归分析。结果 HTWC组患者体质量指数、腰围、臀围、收缩压、空腹血糖、尿酸、甘油三酯、尿白蛋白与肌酐比值较非HTWC组升高（均P〈0.01）;HTWC组DKD的发病率较其他3组高（P〈0.05）。多因素Logistic回归分析表明,HTWC表型是T2DM患者合并DKD的独立危险因素（OR=2.014,95%CI=1.183~3.625）。结论 HTWC表型是T2DM患者合并DKD的独立危险因素。Objective To investigate the association between hypertriglyceridemic-waist phenotype and diabetic kidney disease in patients with type 2diabetes mellitus（T2DM）.Methods According to the cut point of plasma triglycerides concentration≥1.7mmol/L,waist circumference ≥85cm in men or ≥80cm in women,753 patients with T2 DM were divided into four groups：normal waist circumference and triglycerides,normal waist circumference and hypertriglyceridemia,abdominal obesity and normal triglycerides,and hypertriglyceridemic waist（HTWC）group,DKD incidence and correlation indices were compared,and Logistic regression analysis was adopted for study.Results The body mass index,waist circumference,hip circumference,systolic blood pressure,fasting blood-glucose,uric acid,triglycerides and urinary albumin to creatinine ratio in HTWC group were significantly higher than those in nonHTWC groups（all P〈0.01）,as well as DKD incidence（P〈0.05）.Multiple logistic regression analysis revealed that HTWC was an independent risk factor of DKD（OR =2.014,95%CI =1.183-3.625）.Conclusion HTWC pyhenotype is significantly related to DKD incidence in T2 DM patients.

关 键 词：糖尿病 2型 糖尿病肾病 甘油三酯类 腰围 

分 类 号：R587.1[医药卫生—内分泌]