红斑狼疮脱发的研究进展  

Reasearch Progress on Alopecia in Patients with Lupus Erythematosus

作　　者：叶艳婷[1] 章星琪[1] 

机构地区：[1]中山大学附属第一医院皮肤科,广东广州510080

出　　处：《中国医学文摘（皮肤科学）》2016年第4期485-490,共6页China Medical Abstracts(Dermatology)

摘　　要：脱发是红斑狼疮(LE)患者的常见临床表现之一,且与疾病活动性有关,可分为瘢痕性脱发与非瘢痕性脱发两大类,前者为盘状红斑狼疮(DLE)脱发,后者可分为狼疮发、斑状脱发、弥漫性脱发。不同类型的LE脱发在临床、皮肤镜和组织病理学表现上各有特点。红斑狼疮非瘢痕性脱发患者的常见皮肤镜表现包括毛细血管扩张、毛干直径差异明显及色素减退、头皮色素沉着、白点征、褐色毛周征等。LE患者的非瘢痕性斑状脱发在临床和皮肤镜表现有异于斑秃。LE脱发的治疗要及时和适宜,尤其是早期DLE脱发患者治疗后毛发可部分再生,非瘢痕性脱发患者可基本痊愈。Alopecia is a common clinical presentation of lupus erythematosus（ LE）,and is correlated to the disease activity. Alopecia of LE can be divided into two major categories：cicatricial alopecia and non-cicatricial alopecia. Discoid lupus erythematosus（ DLE）is the typical cicatricial alopecia,while non-cicatricial alopecia could be divided into lupus hair,patchy alopecia,and diffuse effluvium. These types of alopecia differ from each other in clinical,dermoscopic and histopathological manifestations. The dermoscopic features of non-cicatricial alopecia in LE include angiotelectasis,hair shaft thinning and hypopigmentation,honeycomb pigment patterns,white dots and peripilar sign. Non-cicatricial patchy alopecia of LE patients differs from alopecia areata on clinical presentation and dermoscopic features. Alopecia of LE should be treated timely and appropriately,especially the hair would partly regrow in patients with early DLE type alopecia after treatment,while patients with non-cicatricial alopecia can be recovered completely.

关 键 词：红斑狼疮 脱发 皮肤镜表现 组织病理学 治疗 

分 类 号：R593.24[医药卫生—内科学] R758.71[医药卫生—临床医学]