威灵仙不同炮制品抗炎镇痛作用的研究  

Research on the anti-inflammation and analgesic effect of different processed products of Clematis

作　　者：刘仕琦[1] 李菲[1] 李俊莲[1] 罗秀夏[1] 

机构地区：[1]山西中医学院,山西太原030024

出　　处：《山西中医学院学报》2016年第4期16-18,共3页Journal of Shanxi College of Traditional Chinese Medicine

基　　金：山西省高校131人才工程项目;山西省国际合作项目(2014081049-6)

摘　　要：目的:研究威灵仙生品及不同炮制品的抗炎镇痛作用。方法:选用醋酸扭体实验、二甲苯诱导小鼠耳肿胀实验和蛋清致大鼠足肿胀实验,观察威灵仙生品及不同炮制品的抗炎作用。结果:醋炙威灵仙能明显减少冰醋酸所致的小鼠扭体次数(P<0.01);生品威灵仙、醋炙威灵仙、酒炙威灵仙均能明显抑制二甲苯引起的小鼠耳廓肿胀(P<0.01);醋炙威灵仙在造模后2 h能明显抑制蛋清所致大鼠足肿胀(P<0.05)。结论:威灵仙生品及酒炙、醋炙品均具有一定的抗炎、镇痛作用,其中醋炙品作用效果最好。Objective：To evaluate the anti-inflammation and analgesic effect of different processed products of Clematis. Methods：The analgesic and the anti-inflammation effects of different processed products of Clematis were studied by writhing response,exploring in the xylene-induced ear swelling model in mice,and egg white-induced paw edema in rats. Results：Clematis by stir-heating with rice vinegar can significantly prolonge the latency and reduce the writhe number at the turning of trunk model in Kun-Ming mice（P〈0.01）. Clematis,Clematis by stir-heating with rice vinegar and wine have good anti-inflammatory effect on inhibiting xylene-induced ear swelling （P〈0.01）. Clematis by stir-heating with rice vinegar can also reduce rats foot-plate swelling in 2 hour （P〈0.05）. Conclusion：The results demonstrate that different processed products of Clematis can release the pain,suppress the inflammation. The effect of Clematis by stir-heating with rice vinegar is the best.

关 键 词：威灵仙 醋炙 酒炙 抗炎 镇痛 

分 类 号：R285.5[医药卫生—中药学]