红细胞分布宽度鉴别急性肠系膜缺血诊断价值的系统评价  

Red blood cell distribution width as biomarker for diagnosing acute mesenteric ischemia: a systematic review and meta-analysis

作　　者：胡琼英[1] 张爽[1] 曾瑜[1] 马韬[1] 张朝明[1] 

机构地区：[1]成都中医药大学附属医院检验科,四川成都610072

出　　处：《泸州医学院学报》2016年第4期361-365,共5页Journal of Luzhou Medical College

基　　金：成都中医药大学科技发展基金(030029045)

摘　　要：目的：系统评价红细胞分布宽度（red cell distribution width,RDW）对急性肠系膜缺血（acute mesenteric ischemia,AMI）的诊断价值。方法：在＂MEDLINE数据库＂、＂EMBASE数据库＂、＂Cochrane系统评价图书馆＂、＂中国生物医学文献数据库＂、＂维普中文科技期刊数据库＂和＂万方数据知识服务平台＂系统检索截止2015年8月以前的相关研究,以RDW、AMI和已报道诊断价值的诊断性试验为纳入标准,对所筛选的文献进行纳入和排除,提取数据进行统计学分析。结果：最终纳入4篇文献进行Meta分析,统计学分析显示RDW对AMI诊断价值范围：灵敏度（sensitivity）0.41～0.88;特异度（specificity）0.54～0.92,阳性似然比（positive likelihood ratio）1.49～8.73;阴性似然比（negative likelihood ratio）0.16～0.73;诊断优势比（diagnostic odds ratio）2.59～28.06。结论：纳入文献的研究仍有局限,RDW对AMI的诊断价值还需进一步研究。Objective： This study performed a systematic review and meta-analysis to evaluate the diagnostic accuracy of using red cell distribution width（RDW） for acute mesenteric ischemia（AMI）. Methods：We have systematically searched the cochrane central register of controlled trials, MEDLINE, EMBASE, the Chinese biomedical miterature database, the china academic journals full-text database, and the Chinese scientific Journals Database using keywords red cell distribution width or RDW, acute mesenteric ischemia, and diagnostic values till August 2015. Results： Four studies were included in this meta-analysis. The ranges of the diagnostic value of RDW for AMI were as follows： sensitivity was 0.41 ～ 0.88; specificity was 0.54 ～ 0.92; positive likelihood ratio was 1.49 ～ 8.73; negative likelihood ratio was 0.16 ～ 0.73; and diagnostic odds ratio was 2.59 ～ 28.06.Conclusion： As a diagnostic biomarker, the diagnostic values of RDW for AMI might not be perfect enough since there were several limitations in those studies.

关 键 词：红细胞分布宽度 急性肠系膜缺血 系统评价 

分 类 号：R446.111[医药卫生—诊断学]