应用动物模型研究氨基酮戊酸光动力治疗皮肤病的研究进展  

The use of animal models in researches on aminolevulinic acid-based photodynamic therapy for the treatment of skin diseases

作　　者：张国龙[1] 周倩[1] 王秀丽[1] 

机构地区：[1]上海市皮肤病医院光医学治疗科同济大学医学院光医学研究所,200443

出　　处：《国际皮肤性病学杂志》2016年第5期409-412,共4页International Journal of Dermatology and Venereology

基　　金：国家自然科学基金（81201222、81472538）;上海市自然科学基金（15411950302）

摘　　要：氨基酮戊酸光动力疗法是一种无创、有效且不良反应和毒副作用少的治疗技术，已广泛地应用于皮肤科领域多种疾病的治疗。动物模型是研究氨基酮戊酸光动力疗法治疗疗效及机制的重要方法。近年来，通过应用皮肤肿瘤、光老化、痤疮、瘢痕以及银屑病的动物模型，优化了氨基酮戊酸光动力疗法治疗参数，进一步阐明了氨基酮戊酸光动力疗法的治疗机制，为氨基酮戊酸光动力疗法增敏剂的开发和应用提供了理论基础。Aminolevulinic acid-based photodynamic therapy （ALA-PDT）, a kind of non-invasive and effective treatment strategy with less adverse effects, has been widely applied in the treatment of various diseases in dermatology. Animal models are an important means to assess therapeutic effects and mechanisms of ALA-PDT. In recent years, the use of animal models for skin neoplasms, photoaging, acne, scar and psoriasis have optimized treatment parameters of ALA-PDT, further clarified therapeutic mechanisms of ALA-PDT, and provided theoretical basis for the development and application of sensitizers in ALA-PDT.

关 键 词：皮肤疾病 氨基酮戊酸 光化学疗法 模型 动物 小鼠 兔 

分 类 号：R751.05[医药卫生—皮肤病学与性病学] R-332[医药卫生—临床医学]