吉非替尼脂质体对S180荷瘤小鼠生存时间及生命质量的影响  

Effect of gefitinib liposomes on survival time and quality of life of mice bearing S180 tumor

作　　者：何琳[1] 马海英[1] 

机构地区：[1]中国医科大学附属第四医院药学部,辽宁沈阳110032

出　　处：《药物评价研究》2016年第3期403-407,共5页Drug Evaluation Research

摘　　要：目的考察吉非替尼(GFB)脂质体对S180荷瘤小鼠生存时间及生命质量的影响。方法 30只小鼠制备S180荷瘤模型,随机分为5组:模型组,GFB低、高剂量溶液(GFB-S-20、GFB-S-40)组,GFB低、高剂量脂质体(GFB-L-20、GFB-L-40)组,低、高剂量为20、40 mg/kg。观察荷瘤小鼠的生存时间、体质量和肿瘤体积的增长情况,并以为自主活动次数为指标,评价小鼠的生命质量。结果与模型组比较,GFB组的生存时间明显延长(P<0.05、0.01),GFB-L-40组生存时间显著长于GFB-S-40组(P<0.05);模型组小鼠体质量增长最快;肿瘤生长速度大小顺序为:模型组>GFB-S-20组>GFB-S-40组>GFB-L-20组>GFB-L-40组;GFB显著改善荷瘤小鼠自主活动次数下降,相同剂量的溶液和脂质体组之间存在显著性差异(P<0.05)。结论 GFB脂质体明显延长了S180荷瘤小鼠的生存时间,提高了生命质量,效果优于溶液组。Objective To investigate the effects of gefitinib （GFB） liposomes on survival and quality of life of mice bearing S 180 tumor. Methods The animal model bearing S180 tumor was established in 30 mice. The mice were randomly divided into five groups： model group, low-, high-dose GFB （GFB-S-20, GFB-S-40） groups, and low-, high-dose GFB liposomes （GFB-L-20, GFB-L-40） groups, and the administration of GFB solutions and GFB liposomes were 20 and 40 mg/kg. The growth and survival of mice bearing S180 tumor were observed for statistical analysis. The number of autonomic activity was used as indiactor to evaluate the quality of life of S 180 tumor-bearing mice. Results Compared with model group, the survival time of the mice in GFB group was significantly longer （P 〈 0.05, 0.01）, the survival time of GFB-L-40 group was significantly longer than that of GFB-S-40 group （P 〈 0.05）, and body weight growth of model group was the fastest; The order of tumor growth speed was as follows ： model group 〉 GFB-S-20 group 〉 GFB-S-40 group 〉 GFB-L-20 group 〉 GFB-L-40 group; GFB significantly improved the number decreasing of autonomic activities of tumor bearing mice, and there was significant difference between the same dose of solution and liposome group （P 〈 0.05）. Conclusions GFB liposomes could prolong the survival time and improve the quality of life obviously in S 180 bearing mice, which is better than GFB solution.

关 键 词：吉非替尼 脂质体 S180荷瘤小鼠 生存时间 生命质量 

分 类 号：R965[医药卫生—药理学]