核因子E2相关因子2对脓毒症胰腺损伤保护作用的研究  

The protective effect of nuclear factor-E2-related factor 2 in secondary pancreatic injury in sepsis

作　　者：颜海鹏[1] 祝益民[2] 

机构地区：[1]南华大学儿科学院湖南省儿童医院,长沙410007 [2]湖南省人民医院,长沙410005

出　　处：《中国小儿急救医学》2016年第8期552-555,共4页Chinese Pediatric Emergency Medicine

基　　金：国家十二五科技支撑计划（2012BA104801）;湖南省科技厅项目（2012TT2003）;南华大学创新项目（2015XCX56）

摘　　要：脓毒症是重症患儿继发胰腺损伤的重要原因，胰腺急性损伤后可引起炎症介质大量释放，加剧机体炎症反应及应激状态，使病情进一步恶化。核因子E2相关因子2（nuclear factor—E2-related factor2，Nrf2）是人体重要的保护性转录因子，可激活人类基因组中500多种基因的表达，其中大部分具有细胞保护作用。研究证实Nrf2具有的细胞保护作用主要包括调控炎症反应、抗氧化应激、改善线粒体功能、减弱毒性蛋白的聚集等。本文就Nrf2保护脓毒症导致胰腺损伤的主要机制作一综述。Sepsis is a major cause of secondary pancreatic injury in critically ill children. A large number of inflammatory mediators were released after acute injury of the pancreas, which may aggravate the inflammatory reaction and the stress reaction. Nuclear factor E2-related factor 2 （Nrf2）, an important protective transcription factor, could activate the expression of more than 500 genes. Most of the genes have the function of cytoprotection. Studies have demonstrated that Nrf2 plays a certain role in cytoprotection, such as regulating the inflammatory response, anti-oxidative stress, improving mitochondrial function and decreasing toxic protein aggregation. This review explored the protective mechanism of Nrf2 in pancreatic injury caused by sepsis.

关 键 词：脓毒症 胰腺损伤 核因子 E2相关因子2 

分 类 号：R720.597[医药卫生—急诊医学]