Blood compatibility of zinc-calcium phosphate conversion coating on Mg-1.33Li-O.6Ca alloy  

作　　者：Yu-Hong ZOU Rong-Chang ZENG Qing-Zhao WANG Li-Jun LIU Qian-Qian XU Chuang WANG Zhi-Wei LIU 

机构地区：[1]College of Chemical and Environmental Engineering, Shandong University of Science and Technology, Qingdao 266590, China [2]College of Materials Science and Engineering, Shandong University of Science and Technology, Qingdao 266590, China [3]Hospital of Shandong University of Science and Technology, Qingdao 266590, China [4]State Key Laboratory of Mining Disaster Prevention and Control Co-founded by Shandong Province and the Ministry of Science and Technology, Shandong University of Science and Technology, Qingdao 266590, China

出　　处：《Frontiers of Materials Science》2016年第3期281-289,共9页材料学前沿（英文版）

基　　金：This work was supported by the National Natural Science Foundation of China （Grant No. 51571134） and SDUST Research Fund （2014TDJH104）. Thanks also go to Prof. Rongshi Chen for the alloy fabrication in Institute of Metal Research, Chinese Academy of Sciences and Ms. Xin-Xin Sun for the coating preparation in Shandong University of Science and Technology.

摘　　要：Magnesium alloys as a new class of biomaterials possess biodegradability and biocompatibility in comparison with currently used metal implants. However, their rapid corrosion rates are necessary to be manipulated by appropriate coatings. In this paper, a new attempt was used to develop a zinc-calcium phosphate （Zn-Ca-P） conversion coating on Mg-1.33Li-0.6Ca alloys to increase the biocompatibility and improve the corrosion resistance. In vitro blood biocompatibility of the alloy with and without the Zn-Ca-P coating was investigated to determine its suitability as a degradable medical biomaterial. Blood biocompatibility was assessed from the hemolysis test, the dynamic cruor time test, blood cell count and SEM observation of the platelet adhesion to membrane surface. The results showed that the Zn-Ca-P coating on Mg-1.33Li-0.6Ca alloys had good blood compatibility, which is in accordance with the requirements for medical biomaterials.Magnesium alloys as a new class of biomaterials possess biodegradability and biocompatibility in comparison with currently used metal implants. However, their rapid corrosion rates are necessary to be manipulated by appropriate coatings. In this paper, a new attempt was used to develop a zinc-calcium phosphate （Zn-Ca-P） conversion coating on Mg-1.33Li-0.6Ca alloys to increase the biocompatibility and improve the corrosion resistance. In vitro blood biocompatibility of the alloy with and without the Zn-Ca-P coating was investigated to determine its suitability as a degradable medical biomaterial. Blood biocompatibility was assessed from the hemolysis test, the dynamic cruor time test, blood cell count and SEM observation of the platelet adhesion to membrane surface. The results showed that the Zn-Ca-P coating on Mg-1.33Li-0.6Ca alloys had good blood compatibility, which is in accordance with the requirements for medical biomaterials.

关 键 词：magnesium alloy LITHIUM biomaterial BIOCOMPATIBILITY zinc-calciumphosphate coating 

分 类 号：TQ328.8[化学工程—合成树脂塑料工业] TQ174.758