解整合素-金属蛋白酶33基因多态性与慢性阻塞性肺疾病易感性的荟萃分析  

Polymorphisms of the ADAM33 gene and chronic obstructive pulmonary disease susceptibility： a meta-analysis

作　　者：邵有和[1] 何志义[1] 陈欢[1] 陈昌枝[1] 冯洁美[1] 

机构地区：[1]广西贵港市人民医院呼吸内科,537100

出　　处：《国际呼吸杂志》2016年第16期1215-1220,共6页International Journal of Respiration

摘　　要：目的：运用荟萃分析的方法探讨解整合素-金属蛋白酶33（ADAM33）基因多态性与慢性阻塞性肺疾病（COPD）易感性的关系。方法：全面检索PubMed、中国知网、重庆维普中文科技期刊全文数据库、万方科技期刊全文数据库获取解整合素-金属蛋白酶33基因多态性与COPD易感性的病例对照研究，根据纳入及排除标准筛选文献并提取数据。采用等位基因遗传模型、显性遗传模型、隐性遗传模型、共显性遗传模型分别评价COPD发病的相对危险度，合并效应采用比值比（OR）和95％可信区间（95％CI）。并通过人种分组，对各基因多态性进行亚组分析。发表偏倚通过漏斗图直观判断和Egger回归法、Begg秩相关法检验。结果：共6篇文献（6个病例-对照研究）被纳入，共有2371例研究对象（其中1174例为COPD患者，1197例为正常对照者）被纳入荟萃分析。Meta分析结果表明，无论在亚洲人还是高加索人中，ADAM33 F＋1基因多态性与COPD易感性无关联。而Q-1 G/A与亚洲人种COPD患者易感性无关（OR=1.289，95％C1= 0.759-2.190,P= 0.347），与高加索人种COPD易感性有关（OR=1.651，95％C1=1.178-2.314,P= 0.004）。ADAM33 Q-1 G/A与COPD有关联（OR=1.421,95％CI=1.014-1.991, P= 0.042）。亚组分析显示，Q-1 G/A基因多态性与亚洲人COPD易感性无关（OR=1.289，95％C1= 0.759-2.190,P= 0.347）；与高加索人COPD易感性有关（OR=1.651，95％C1=1.178-2.314,P= 0.004）。结论： ADAM33 F＋1T/C基因多态性可能与慢性阻塞性肺疾病易感性没有相关性，ADAM 33Q-1G/A等位基因G可能是慢性阻塞性肺疾病的易感因素。0bjective To explore the association between the F＋1（rs511898）, Q-1（rs612709）pulmonary of A Disintegrin And Metalloproteases33 （ADAM33）gene and Chronic Obstructive Pulmonary Disease（COPD） susceptibility using the method of meta analysis. Methods Comprehensive searches were performed of PubMed, Ovid database, Wanfang, Chinese National Knowledge Infrastructure database and Chongqing VIP database obtaining the related case-control studies. The included studies were selected according to inclusion criteria. The pooled odds ratios were performed respectively for allele comparison, additive genetic model, dominant genetic model and recessive genetic model.The association between ADAM33 gene polymorphism and COPD susceptibility was measured by OR and 95%CI.The subgroup analysis was distinguished according to the ethnicity. The publication bias was tested by Begg＇s funnel plots and Egger＇s linear regression method. Results Six literatures（six case-control studies）,comprising 2371 participants（1174 patients with COPD and 1197 controls）were included in the meta-analysis. The results showed no significant association between ADAM33 F＋1 polymorphism and COPD susceptibility, and the same result was showed in subgroup analysis. ADAM33 Q-1 G/A has association with COPD susceptibility （OR=1.421,95%CI=1.014-1.991, P= 0.042）. In subgroup analysis,Q-1 G/A was not associated with the susceptibility of COPD in the Asian population（OR=1.289,95%C1= 0.759-2.190,P= 0.347）;Q-1 G/A was associated with the susceptibility of COPD in the Caucasian population（OR=1.651,95%C1=1.178-2.314,P= 0.004）.Conclusions There is may no association between ADAMM33 F＋1 T/C polymorphism and COPD susceptibility. The ADAMM33 Q-1 G/A allele G may be the susceptible factor to COPD.

关 键 词：慢性阻塞性肺疾病 解整合素-金属蛋白酶33 基因多态性 META分析 

分 类 号：R563.9[医药卫生—呼吸系统]