慢性阻塞性肺疾病急性加重期患者血浆中肌钙蛋白Ⅰ、脑钠肽及血尿酸测定的临床意义  

Clinical study of determination of plasma cTn Ⅰ , BNP and UA levels in patients with acute elevated chronic obstructive pulmonary disease

作　　者：王宝俊[1] 王华[1] 张金莲[1] 

机构地区：[1]包头市第八医院呼吸内科,014040

出　　处：《国际呼吸杂志》2016年第16期1225-1227,共3页International Journal of Respiration

摘　　要：目的 探讨血浆肌钙蛋白Ⅰ、脑钠肽及血尿酸水平测定对急性加重期慢性阻塞性肺病患者的临床意义。方法 选取166例急性加重期慢性阻塞性肺病患者为研究组，根据病情严重程度分为轻度、中度、重度及治疗后稳定期组，采用化学发光免疫分析各组患者血浆中的肌钙蛋白Ⅰ与脑钠肽水平，同时生化法测定血尿酸水平并与40例健康对照组进行比较。结果166例急性加重期慢性阻塞性肺病患者血浆中肌钙蛋白Ⅰ、脑钠肽及血尿酸水平显著高于健康对照（P＜0.05），并且患者血浆中肌钙蛋白Ⅰ、脑钠肽及血尿酸水平随病情严重程度而增加，重度组患者显著高于轻度及中度组患者（P＜0.05），治疗后稳定期组患者与健康对照血浆中肌钙蛋白Ⅰ、脑钠肽及血尿酸水平无显著差异（P＞0.05）。结论 血浆肌钙蛋白Ⅰ、脑钠肽及血尿酸水平是对急性加重期慢阻肺病的诊断和严重程度评估的有效指标，有一定的临床推广应用价值。Objective To explore clinical diagnosis and therapy study of determination of plasma cardiac troponin Ⅰ （cTn Ⅰ ）, brain natriuretic peptide （BNP） and uric acid （UA） in patients with acute elevated chronic obstructive pulmonary disease （AECOPD）. Methods Select 166 cases of tuberculosis in patients with acute exacerbation of chronic obstructive study group, according to the severity of the disease is divided into grade Ⅰ, grade Ⅱ and Ⅲ level and stable after treatment group. The levels of plasma cTn Ⅰ, BNP and UA were determined in 166 patients with AECOPD as well as 40 controls and done study compared. Results The plasma cTn Ⅰ, BNP and UA levels in 166 patients with AECOPD were significantly higher than those in the controls （ P 〈0.05）, and they were increased with advanced degree Ⅰ -Ⅲ stage of AECOPD. But the plasma cTn Ⅰ , BNP and UA levels in patients after therapy were not much different from those in controls （ P〈0.05）. Conclusions The plasma cTn Ⅰ , BNP and UA levels were effect tools of diagnosis and reflect the severity of the AECOPD and determination of which were of great clinical importance after therapy.

关 键 词：慢性阻塞性肺疾病急性加重期 肌钙蛋白Ⅰ 脑钠肽 尿酸 

分 类 号：R563.9[医药卫生—呼吸系统]