噁唑啉类配体在钯催化烯烃的不对称氧化官能化反应中的应用  

Application of Oxazoline Ligands in Palladium-Catalyzed Asymmetric Oxidative Functionalization of Alkenes

作　　者：刘小建[1] 陈品红[2] 吴范宏[1] 

机构地区：[1]上海应用技术学院化学与环境工程学院,上海201418 [2]中国科学院上海有机化学研究所金属有机化学国家重点实验室,上海200032

出　　处：《有机化学》2016年第8期1797-1804,共8页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(No.21472217)资助项目~~

摘　　要：钯催化烯烃的官能化反应是实现简单烯烃向复杂分子转化的高效方法之一,尤其是烯烃的氧化官能化反应,能够更加高效地得到烯烃的双官能化的产物,其不对称反应也受到化学家们的广泛关注.但是在氧化双官能化反应中,要求手性配体能够耐氧化.近年来的研究表明,噁唑啉配体在这类反应中是能够兼容的,而且可以得到优秀的对映选择性.本综述介绍了近期噁唑啉配体在钯催化烯烃的氧化官能化反应中的应用进展.Palladium-catalyzed oxidative functionalization of alkenes is one of the most powerful tools to synthesize complicated molecules. The related asymmetric reactions have received much attention. Due to the oxidative condition, however, compatible chiral ligand is quite limited. Recently, oxazoline-type ligand was applied in these reactions and exhibited good to excellent enantioselectivity. In this review, the recent studies on palladium-catalyzed asymmetric oxidative functionalization of alkenes with oxazoline ligands were summarized.

关 键 词：噁唑啉 钯 烯烃 不对称催化 

分 类 号：O621.251[理学—有机化学]