激素性股骨头坏死发病机制中细胞凋亡的研究进展  

Research progress of apoptosis in the pathogenesis of glucocorticoid-induced necrosis of the femoral head

作　　者：陈宝琅[1] 

机构地区：[1]菏泽医学专科学校生理学教研室,山东菏泽274000

出　　处：《中国当代医药》2016年第19期12-15,共4页China Modern Medicine

基　　金：山东省教育厅科研发展计划项目(J05L55)

摘　　要：在骨科临床诊断治疗过程中,股骨头坏死是一项比较困难的课题,在临床诊疗过程中过多地使用激素类药物,使得该病的发病率也在逐渐提升。目前,该病的发病机制尚未完全明确,存在着一定争议。激素性股骨头坏死的治疗方式还处于探索阶段,还不能够从病因学的角度来展开有效的治疗干预。有研究在坏死的股骨头标本中发现了凋亡细胞,这使人们的注意力也转向了对细胞凋亡领域的研究。本文对细胞凋亡与激素性股骨头坏死发病机制之间存在的联系进行综述。In the process of clinical diagnosis and treatment in the department of orthopedics,the necrosis of the femoral head is a difficult task,due to excessive use of glucocorticoid in the clinical diagnosis and treatment process,the incidence rate of glucocorticoid-induced necrosis of the femoral head is gradually improving.At present,the pathogenesis of the glucocorticoid-induced necrosis of the femoral head is not completely clear,there is a certain controversy.The treatment of glucocorticoid-induced necrosis of the femoral head is still in the exploratory stage,and it is not able to expand effective therapeutic intervention from the view of etiology.Apoptosis have been found in the necrotic femoral head,which has turned the attention of people to the field of apoptosis.The relationship between apoptosis and the pathogenesis of glucocorticoid-induced necrosis of the femoral head is reviewed in this paper.

关 键 词：激素性股骨头坏死 发病机制 细胞凋亡 研究进展 

分 类 号：R681.8[医药卫生—骨科学]