桃红四物汤治疗冠心病的机制研究进展  

Research progress on the mechanism of Taohong Siwu decoction in the treatment of coronary atherosclerotic heart disease

作　　者：冒慧敏[1,2] 刘秀华[3] 史大卓[2] 

机构地区：[1]北京中医药大学研究生院,博士研究生100029 [2]中国中医科学院心血管病研究所 [3]中国人民解放军总医院病理生理研究室

出　　处：《环球中医药》2016年第9期1145-1148,共4页Global Traditional Chinese Medicine

基　　金：国家重点基础研究发展计划(973计划)(2015CB554402);国家"十二五"科技支撑计划(2013BAI02B01)

摘　　要：桃红四物汤是活血化瘀的常用方之一,近年来被广泛用于治疗冠心病。研究表明,桃红四物汤可改善冠心病患者的心绞痛症状及心电图缺血的表现,其机制可能与减轻心肌细胞损伤、改善内皮细胞功能、抑制血管平滑肌细胞增殖和迁移、抑制血小板聚集和活化、抑制炎症反应、改善血脂代谢相关。但纵观桃红四物汤对冠心病的机制研究,仍存在一定的局限性,应进一步明确其治疗冠心病的分子生物学作用机制,开展高质量的随机对照研究,以期为桃红四物汤治疗冠心病的临床应用提供依据。Taohong Siwu decoction is the commonly-used prescription for promoting blood circulation and removing blood stasis,and the prescription has been widely used in coronary atherosclerotic heart disease（ CAHD）. It is reported that Taohong Siwu decoction can relieve angina symptoms and improve electrocardiogram（ ECG）. The possible mechanisms may be related to reducing myocardial cell damage,improving endothelial function,inhibiting the proliferation and migration of vascular smooth muscle cells,inhibiting platelet aggregation and activation,inhibiting inflammatory reaction and improving blood lipid metabolism. However,there are several limitations of the relevant articles. More researches should be conducted on the mechanisms and clinical effects of Taohong Siwu decoction for CAHD patients,to provide evidence for clinical application of Taohong Siwu decoction.

关 键 词：桃红四物汤 冠心病 临床研究 机制 

分 类 号：R541.4[医药卫生—心血管疾病]