蒙药孟根乌森乌日乐长期毒性研究  

The Study of long-term Toxicity of mongolian medicine Meng gen wu sen wu ri le

作　　者：青玉[1] 巴图德力根[1] 韩志强[1] 塔娜[2] 

机构地区：[1]内蒙古民族大学附属医院蒙药药理研究所,通辽028007 [2]内蒙古民族大学蒙医药学院,通辽028000

出　　处：《中药药理与临床》2016年第3期147-150,共4页Pharmacology and Clinics of Chinese Materia Medica

基　　金：国家"十二五"科技支撑计划基金资助项目(2012BAI27B0204)

摘　　要：目的:研究孟根乌森乌日乐对大鼠的长期毒性实验,为临床提供安全用药依据。方法:取Wister大鼠,按体重随机分为孟根乌森乌日勒0.05 g/kg组、0.10g/kg组、0.52g/kg组,每天一次灌胃给药,连续90天,观察给药后大鼠一般健康状况、生长发育、毒性反应、外围血象、肝肾功能、肾早期损伤指标,病理检查等。结果:0.05 g/kg组、0.10g/kg组、0.52g/kg组3个剂量的大鼠一般健康状况、生长发育、外围血象、肝肾功能均无影响、肾早期损伤指标,病理检查亦无明显变化,无明显毒性反应,未见与药物作用有关的病理变化。结论:孟根乌森乌日乐在大于人临床用药剂量100倍,连续给药3个月时,对大鼠是安全的。Objective： To study long-term toxicity experiments of mongolian medicine Meng gen wu sen wu rile on rats. Methods： Mongolian med- icine Meng gen wu sen wu rile was administered orally 0.05g/kg,0.10g/kg,0.52 g/kg dose, once a day for90 days, to observe general heahh ,growth and development, toxicity, peripheral blood,liver and kidney function, early indicators of kidney damage,pathological examina- tion on rat after administration. Results： general health,growth and development,peripheral blood,liver and kidney function of rat in 0.05g/ kg,0.10g/kg,0.52 g/kg dose group had no effect, and early indicators of kidney damage and pathological changes have no toxicity effect,no pathological changes with drug effect. Conclusion： Mongolian medicine Meng gen wu sen wu rile were safe and reliable for greater than 100 times the human clinical dose, continuous administration 90 days on rats.

关 键 词：孟根乌森乌日乐 长期毒性实验 大鼠 

分 类 号：R29[医药卫生—民族医学]