益气活血化瘀汤联合西治疗慢性阻塞性肺疾病急性加重期随机平行对照研究  

A Randomized Parallel Controlled Study on the Treatment of Chronic Obstructive Pulmonary Disease with Acute Exacerbation Yiqi Huoxue Huayu Tang(益气活血化瘀汤) Combined with Western Medicine

作　　者：张剑辉[1] 

机构地区：[1]惠州市中心人民医院中医科,广东惠州516000

出　　处：《实用中医内科杂志》2016年第9期49-52,共4页Journal of Practical Traditional Chinese Internal Medicine

摘　　要：[目的]观察益气活血化瘀汤联合西药治疗慢性阻塞性肺疾病急性加重期疗效。[方法]使用随机平行对照方法,将70例门诊患者按就诊顺序号方法随机分为两组。对照组35例纠正水电解质紊乱,控制性氧疗,支气管扩张剂、抗生素、糖皮质激素等治疗以及营养支持。治疗组35例益气活血化瘀汤(黄芪15g,葶苈子20g,赤芍、桔梗、桃仁、丹参、川芎、当归、红花各10g;热盛加金银花、黄芩各20g;严重胸闷加枳壳15g;严重喘促加苦杏仁、厚朴、款冬花各10g),1剂/d,水煎400m L,早晚口服;西药治疗同对照组。连续治疗10d为1疗程。观测临床症状、全血高切黏度、血浆黏度、全血低切黏度、红细胞聚集指数、FEV_1/FVC、FEV_1、不良反应。连续治疗3疗程,判定疗效。[结果]治疗组临床控制7例,显效16例,有效10例,无效2例,总有效率94.30%;对照组临床控制3例,显效11例,有效15例,无效10例,总有效率71.40%;治疗组疗效优于对照组(P<0.05)。血液流变学指标两组均有改善(P<0.05,P<0.01),治疗组改善优于对照组(P<0.05,P<0.01)。肺功能指标两组均有改善(P<0.01),两组间无明显差异(P>0.05)。[结论]益气活血化瘀汤联合西药治疗慢性阻塞性肺疾病急性加重期,疗效满意,无严重不良反应,值得推广。[Objective] To observe the effect of YQHXHYT Combined with western medicine in the treatment of chronic obstructive pulmonary disease with acute exacerbation. [Method] Using random parallel control method, 70 cases （hospital/clinic） patients （pathography, according to draw/visiting sequence number） method were randomly divided into two groups. The control group of 35 cases of correct water electrolyte disorder, controlled oxygen therapy, and nutritional support of bronchodilators, antibiotics, glucocorticoid therapy. Treatment group （n=35） YQHXHYT （Radix Astragali 15 g, pepperweed seed 20 g, red peony root, Platycodon root, peach kernel, radix salviae miltiorrhizae, Rhizoma Chuanxiong, angelica, safflower each 10 g; the Reshengjia honeysuckle, Baikal Skullcap Root 20 g; severe chest tightness and Fructus aurantii 15 g; Yan Zhongchuan promoting and bitter almond, Magnolia, cohsfoot flower each 10 g）, daily 1 agent, water decoction 400 mL, sooner or later, oral; western medicine in the treatment of with the control group. Continuous treatment for 1 courses of 10d. Observation of clinical symptoms, blood rheology study indexes （blood viscosity, plasma viscosity, low blood shear viscosity, erythrocyte aggregation index）, lung function （FEV1/FVC, FEV0 and adverse reactions. Continuous treatment for 00 courses of treatment, to determine efficacy. Group than in the control group. [Results] Treatment group, clinical control in 7 cases, effective in 16 cases, 10 cases were effective, 2 cases ineffective, efficiency 94.30%; control group, clinical control in 3 cases, 11 cases were markedly effective, effective in 15 cases, 10 cases ineffective, 71.40% efficiency; the treatment group curative effect surpasses the control group （P 〈0.05）. The blood rheology indexes of two groups were improved （P〈0.05, P〈O.01）, the treatment group was better than the control group （P〈0.05, P〈0.01）. The lung function of two groups were improved （P〈O.01）, no significant difference between the tw

关 键 词：慢性阻塞性肺疾病 急性加重期 益气活血化瘀汤 支气管扩张剂 抗生素 糖皮质激素 全血高切黏度 血浆黏度 全血低切黏度 红细胞聚集指数 FEV1/FVC FEV1 中西医结合治疗 随机平行对照研究 

分 类 号：R563[医药卫生—呼吸系统]