自噬在糖尿病肾病进展中的作用及机制  

Role and mechanism of autophagy in progression of diabetic nephropathy

作　　者：陈客宏[1] 何娅妮[1] 

机构地区：[1]第三军医大学大坪医院肾内科,重庆400042

出　　处：《中华肾病研究电子杂志》2016年第4期172-176,共5页Chinese Journal of Kidney Disease Investigation（Electronic Edition）

基　　金：国家自然科学基金(81670661;81400733)

摘　　要：糖尿病肾病是导致终末期肾脏疾病的主要病因之一,其发病机制不清。自噬是一种高度保守的细胞学事件,能够降解细胞内异常蛋白和细胞器,维持细胞内环境稳定,在多种急慢性肾脏疾病中发挥着重要的作用。研究发现糖尿病肾病中肾脏自噬功能受损,提示自噬障碍可能参与糖尿病肾病发病。本文将针对肾脏不同类型细胞,对自噬在糖尿病肾病中作用的相关研究进展进行综述。Diabetic nephropathy is one of the main causes for end-stage renal disease,whose pathogenesis is unclear yet.Autophagy is a highly conserved cytology event which can degrade intracellular abnormal proteins and organelles,maintaining the intracellular homeostasis and playing a critical role in many acute and chronic kidney diseases.It was demonstrated that impairment of autophagy is implicated in the pathogenesis of diabetic nephropathy.Focusing on different types of cells in the kidneys,this article reviewed related progress of research on the role of autophagy in diabetic nephropathy.

关 键 词：自噬 糖尿病肾病 

分 类 号：R587.2[医药卫生—内分泌]